标题：miRNA let-7a在卵巢癌中的研究进展

      作者：全丽妮 综述 黄守国 审校    中南大学湘雅医学院附属海口医院妇产科，海南 海口 570208

      卷次： 2021年32卷15期

      【摘要】 卵巢癌是女性常见的恶性肿瘤之一，由于病症不明显、缺乏早期诊断方法，且易复发并伴有化疗耐药，成为女性死亡常见原因之一。微小RNA (miRNA)是一种小非编码RNA，普遍存在于真核生物体内，参与体内多种生理、病理过程，其异常表达往往与疾病相关。miRNA let-7a作为较早被发现的miRNA，已在多种肿瘤组织中发现其表达异常，其在卵巢癌中作为抑癌基因呈现低表达，与卵巢癌的发生、发展、耐药及预后密切相关，但let-7a的作用机制复杂，其在卵巢癌中的作用机制还需进一步阐明。
      【关键词】 miRNA let-7a；卵巢癌；早期诊断；化疗耐药；预后
      【中图分类号】 R737.31 【文献标识码】 A 【文章编号】 1003—6350（2021）15—2024—04

Research progress of miRNA let-7a in ovarian cancer.
QUAN Li-ni, HUANG Shou-guo. Haikou Hospital Affiliated toXiangya School of Medicine, Central South University, Haikou 570208, Hainan, CHINA【Abstract】 Ovarian cancer is one of the most common malignant tumors for women. Due to the unconspicuoussymptom, lack of early diagnosis methods, high rate of relapse and chemotherapy resistance, it is among the frequentcauses of female death. As a kind of small non-coding RNA, miRNAs participate in a variety of physiological and patho-logical processes in vivo, which can be easily found in eukaryotes. The abnormal expression of miRNAs is often associat-ed with diseases. miRNA let-7a, an early discovered miRNA, has been detected abnormal expression in many tumor tis-sues. It shows, specifically, low expression as a tumor suppressor gene in ovarian cancer, which is closely related to theoccurrence, development, drug resistance and prognosis of ovarian cancer. However, the mechanism that let-7a effectson ovarian cancer is complex, and thus warrants further clarification.
      【Key words】 microRNA let-7a; Ovarian cancer; Early diagnosis; Chemotherapy resistance; Prognosis·综述·doi:10.3969/j.issn.1003-6350.2021.15.032基金项目：海南省卫生健康行业科研项目(编号：20A200174)