标题：CYBA基因与神经精神疾病相关性的研究进展

      作者：韦雅雪 综述 彭谦，张丹丹，王路路，林举达 审校    广东医科大学，广东 湛江 524001

      卷次： 2021年32卷15期

      【摘要】 大多数神经精神疾病，如精神分裂症、帕金森病等都存在表型异质性，目前确切病因尚不明确，但普遍认为与氧化应激、遗传等多种机制相关。作为编码介导活性氧生成的NADPH酶重要亚基的基因，CYBA基因在上述疾病的发生与发展过程中可能起关键作用，并影响临床症状严重程度。因此，可作为潜在的临床诊断和诊治的靶点，现就CYBA基因与神经精神疾病的相关研究进展做一综述。
      【关键词】 CYBA基因；帕金森病；精神分裂症；阿尔兹海默病；癫痫
      【中图分类号】 R74 【文献标识码】 A 【文章编号】 1003—6350（2021）15—2020—04

Progress in research on CYBA gene and neuropsychiatry diseases.
WEI Ya-xue, PENG Qian, ZHANG Dan-dan,WANG Lu-lu, LIN Ju-da. Guangdong Medical University, Zhanjiang 524001, Guangdong, CHINA【Abstract】 henotypic heterogeneity exists in most neuropsychiatric diseases, such as schizophrenia and Parkin-son's disease. At present, the exact etiology is not clear, but it is generally believed to be related to oxidative stress, hered-ity, and other mechanisms. As a gene encoding an important subunit of NADPH enzyme mediating the production of re-active oxygen species, CYBA gene may play a key role in the occurrence and development of the above diseases and af-fect the severity of clinical symptoms. Therefore, it can be used as a potential target for clinical diagnosis and treatment.This paper reviews the research progress on the relationship between CYBA gene and neuropsychiatric diseases.
      【Key words】 CYBA gene; Parkinson's disease; Schizophrenia; Alzheimer's disease; Epilepsy·综述·doi:10.3969/j.issn.1003-6350.2021.15.031