标题：阻塞性睡眠呼吸暂停生物标志物的研究进展

      作者：孙锡仕 1 综述 陈日垦 2，成俊芬 3 审校    1.广东医科大学广东医科大学附属医院，广东 湛江 524000；2.呼吸疾病国家重点实验室广州医科大学附属第一医院广州呼吸健康研究院国家呼吸疾病临床研究中心，广东 广州 510120；3.广东医科大学附属第二医院，广东 湛江 524003

      卷次： 2021年32卷15期

      【摘要】 阻塞性睡眠呼吸暂停(OSA)是最常见的睡眠呼吸障碍疾病，它的特点是在睡眠期间反复发作气流停止(呼吸暂停)或减少(低通气)，从而导致低氧血症和睡眠碎片化，这是呼吸相关的频繁唤醒的结果，从而导致睡眠质量下降，并对生活质量产生不利影响。目前认为，OSA与2型糖尿病、高血压、房颤、心力衰竭、冠心病、脑梗塞等多种系统性疾病的发病有关。因此，OSA给公共卫生带来了很大的负担，可见阻塞性睡眠呼吸暂停早诊断非常重要。当前OSA诊断标准是多导睡眠监测，但是多导睡眠监测的局限性使OSA诊断带来不便，从而使OSA患者诊疗延迟。因此，寻找一种检测方便、快捷的生物标记物尤为重要，这也是目前研究的热点。本文主要从基因组学、转录组学、蛋白质组学、代谢组学、炎症性、氧化应激等生物标志物进行综述。
      【关键词】 阻塞性睡眠呼吸暂停；生物标志物；基因组学；转录组学；蛋白质组学；代谢组学；炎症性；氧化应激
      【中图分类号】 R56 【文献标识码】 A 【文章编号】 1003—6350（2021）15—2012—05

Research progress on biomarkers of obstructive sleep apnea.
SUN Xi-shi 1, CHEN Ri-ken 2, CHENG Jun-fen 3. 1. TheAffiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong, CHINA; 2. State Key Laboratory ofRespiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of RespiratoryHealth, National Respiratory Disease Clinical Research Center, Guangzhou 510120, Guangdong, CHINA; 3. The SecondAffiliated Hospital of Guangdong Medical University, Zhanjiang 524003, Guangdong, CHINA【Abstract】 Obstructive sleep apnea (OSA) is the most common sleep-disordered breathing disorder. It is charac-terized by repeated episodes of airflow stop (apnea) or decrease (hypoventilation) during sleep, leading to hypoxemiaand sleep fragmentation. This is the result of frequent arousals related to breathing, which leads to a decline in sleep qual-ity and even adversely affects the quality of life. It is currently believed that OSA is related to the onset of various sys-temic diseases such as type 2 diabetes, hypertension, atrial fibrillation, heart failure, coronary heart disease, and cerebralinfarction. Therefore, OSA has brought a great burden to public health, which shows that early diagnosis of obstructivesleep apnea is very important. Recently, OSA diagnostic standard is polysomnography, but the limitations of polysom-nography make the diagnosis of OSA inconvenient, which delays the diagnosis and treatment of OSA patients. There-fore, it is particularly important to find a biomarker that is convenient and quick to detect, which is also a hot spot of cur-rent research. This article mainly focuses on biomarkers such as genomics, transcriptomics, proteomics, metabolomics,inflammation, and oxidative stress.
      【Key words】 Obstructive sleep apnea (OSA); Biomarkers; Genomics; Transcriptomics; Proteomics; Metabolo-mics; Inflammatory; Oxidative stress·综述·doi:10.3969/j.issn.1003-6350.2021.15.029基金项目：2019年广东省科技专项资金(“大专项+任务清单”)(重大科技创新平台和项目引进专项)项目(编号：2019A201)