标题：SDF-1α/CXCR4轴在心血管系统疾病中的研究进展

      作者：陶冶 1 综述 徐明国 1，2 审校    1.中国医科大学，辽宁 沈阳 110001；2.深圳市儿童医院，广东 深圳 518000

      卷次： 2021年32卷15期

      【摘要】 心血管疾病中多存在内皮细胞损伤病理基础，在以此为基础的心血管疾病治疗中，内皮祖细胞(EPCs)的应用起关键作用，作为血管新生的主要细胞成分，将EPCs移植到局部损伤部位能有效促进血管修复和再内皮化。SDF-1α/CXCER4轴是指基质细胞衍生因子1及其受体CXCR4构成的可影响细胞增殖、运动、生长、归巢等生物学行为的偶联分子对，根据不同SDF-1α的浓度梯度，可有效调控EPCs的增殖、黏附功能从而达到治疗效果。本文总结目前的研究成果，对SDF-1α/CXCR4轴在心血管疾病的研究进展进行综述。
      【关键词】 心血管疾病；内皮祖细胞；SDF-1α/CXCR4轴；趋化因子
      【中图分类号】 R54 【文献标识码】 A 【文章编号】 1003—6350（2021）15—2007—05

Research progress of SDF-1 α / CXCR4 axis in cardiovascular disease.
TAO Ye 1, XU Ming-guo 1,2. 1. China MedicalUniversity, Shenyang 110001, Liaoning, CHINA; 2. Shenzhen Children's Hospital, Shenzhen 518000, Guangdong, CHINA【Abstract】 There are many pathological bases of endothelial cell injury in cardiovascular diseases. In the treat-ment of cardiovascular diseases based on this, the application of endothelial progenitor cells (EPCs) plays a key role. Asthe main component of angiogenesis, transplantation of EPCs to the injured site can effectively promote vascular repairand re-endothelialization. The SDF-1α/CXCER4 axis refers to a pair of coupled molecules composed of stromal cell-de-rived factor 1 and its receptor CXCR4 that can affect cell proliferation, movement, growth, homing and other biologicalbehaviors. According to different concentration gradients of SDF-1α, it can effectively regulate the proliferation and ad-hesion functions of EPCs to achieve therapeutic effects. This article summarizes the current research results and reviewsthe research progress of SDF-1α/CXCR4 axis in cardiovascular diseases.
      【Key words】 Cardiovascular disease; Endothelial progenitor cells; SDF-1α/ CXCR4 axis; Chemokine·综述·doi:10.3969/j.issn.1003-6350.2021.15.028基金项目:国家自然科学基金(编号：81870364)；广东省深圳市三名工程项目(编号：SZSM20162057)