标题：肺癌合并肺部感染患者PIK3CA蛋白表达、血常规指标和凝血指标的变化及临床意义

      作者：王兆邦，梁秋亭，冯家华    东莞市滨海湾中心医院呼吸与危重症医学科，广东 东莞 523900

      卷次： 2021年32卷15期

      【摘要】 目的 探讨肺癌合并肺部感染患者癌基因(PIK3CA)蛋白表达、血常规指标和凝血指标水平的变化及临床意义。方法 回顾性分析2015年1月至2019年12月东莞市滨海湾中心医院收治的40例肺癌合并肺部感染患者(感染组)和 40例肺癌未合并肺部感染患者(未感染组)的临床资料，比较两组患者的PIK3CA蛋白、白细胞计数(WBC)、血小板计数(PLT)、血小板体积分布宽度(PDW)、平均血小板体积(MPV)、中性粒细胞(NEU)、淋巴细胞(LYW)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体(D-D)水平。结果 感染组患者的 PIK3CA蛋白阳性率为 47.50%，明显高于未感染组的 15.00%，差异有统计学意义(P<0.05)；感染组患者的WBC、PDW、MPV、NEU水平分别为 (8.14±1.02)×109/L、(10.72±0.85) fL、(10.56±0.94) fL、(68.13±6.11)%，明显高于未感染组的(6.83±1.48)×109/L、(9.63±1.42) fL、(9.30±1.18) fL、(60.06±4.30)%，PLT、LYW水平分别为(183.34±26.10)×109/L、(22.04±2.74)%，明显低于未感染组的(231.15±21.84)×109/L、(26.82±3.06)%，差异均有统计学意义(P<0.05)；感染组患者的APTT、PT、TT分别为(38.05±1.34) s、(15.38±1.25) s、(17.34±1.28) s，明显长于未感染组的(36.86±1.27) s、(13.02±1.06) s、(16.05±1.41) s，FIB、D-D水平分别为(6.38±0.75) g/L、(2.20±0.36) mg/L，明显高于未感染组的(4.33±0.69) g/L、(1.39±0.22) mg/L，差异均有统计学意义(P<0.05)。结论 肺癌合并肺部感染患者的PIK3CA蛋白阳性表达率明显升高，血常规、凝血功能指标水平均出现异常表达，临床上应予以重视。
      【关键词】 肺癌；肺部感染；PIK3CA蛋白；血常规；凝血功能；临床意义
      【中图分类号】 R734.2 【文献标识码】 A 【文章编号】 1003—6350（2021）15—1919—04

Changes and clinical significance of PIK3CA protein expression, blood routine indexes, and coagulation indexesin lung cancer patients with pulmonary infection.
WANG Zhao-bang, LIANG Qiu-ting, FENG Jia-hua. Department ofRespiratory and Critical Care Medicine, Binhai Bay Central Hospital, Dongguan 523900, Guangdong, CHINA
【Abstract】 Objective To study the changes and clinical significance of oncogene (PIK3CA) expression, bloodroutine indexes and coagulation indexes in lung cancer patients with pulmonary infection. Methods The clinical dataof 40 patients with lung cancer complicated with pulmonary infection (infection group) and 40 patients without lung can-cer complicated with pulmonary infection (non-infection group) in Binhai Bay Central Hospital of Dongguan City fromJanuary 2015 to December 2019 were retrospectively analyzed. The white blood cell count (WBC), platelet count (PLT),platelet volume distribution width (PDW), mean platelet volume (MPV), neutrophils (NEU), lymphocytes (LYW), acti-vated partial thromboplastin time (APTT), prothrombin time (PT), coagulase time (TT), fibrinogen (FIB), D-Dimer(D-D) levels were compared between the two groups. Results The positive rate of PIK3CA protein in infection groupwas 47.50%, which was significantly higher than 15.00% in non-infection group (P<0.05); the WBC, PDW, MPV, andNEU levels in the infection group were (8.14±1.02)×109/L, (10.72±0.85) fL, (10.56±0.94) fL, (68.13±6.11)%, respective-ly, which were significantly higher than corresponding (6.83 ± 1.48) × 109/L, (9.63 ± 1.42) fL, (9.30 ± 1.18) fL, (60.06 ±4.30)% in the non-infection group. The PLT and LYW levels were (183.34±26.10)×109/L and (22.04±2.74)%, whichwere significantly lower than corresponding (231.15±21.84)×109/L and (26.82±3.06)% in non-infection group (all P<0.05); the APTT, PT, and TT in the infection group were (38.05±1.34) s, (15.38±1.25) s, and (17.34±1.28) s, respective-ly, which were significantly longer than corresponding (36.86±1.27) s, (13.02±1.06) s, and (16.05±1.41) s in non-infec-tion group, and the FIB and D-D levels were (6.38±0.75) g/L and (2.20±0.36) mg/L, which were significantly highercorresponding (4.33±0.69) g/L and (6.38±0.75) mg/L in non-infection group (all P<0.05). Conclusion The positiveexpression rate of PIK3CA protein in patients with lung cancer complicated with pulmonary infection is significantlyincreased, and abnormal expression of blood routine and coagulation function indexes are appeared, which should bepaid attention to clinically.
      【Key words】 Lung cancer; Pulmonary infection; PIK3CA protein; Blood routine; Coagulation function; Clinicalsignificance