标题:非甾体药物在骨骼肌损伤中的应用
作者:李健 1,蒋华生 1,谭荣雄 1,蔡杰钦 1 综述 魏波 1,黄春明 2 审校 1.广东医科大学,广东 湛江 524000;2.高州市人民医院,广东 茂名 525000
卷次:
2021年32卷14期
【摘要】 骨骼肌损伤会经历炎症、再生和纤维化等一系列阶段。炎症会引起疼痛,降低骨骼肌生理功能,对运动能力有负面影响。目前非甾体药物常用于骨胳肌损伤后减少炎症,达到缓解疼痛和早期骨骼肌功能锻炼的目的,但非甾体药物的介入是否会破坏骨骼肌损伤修复的正常过程,从而阻碍骨骼肌损伤修复。本综述收集相关文献来评估非甾体药物治疗对骨骼肌损伤的影响,以期为临床用药提供相关理论依据,指导治疗。
【关键词】 非甾体类药物;骨骼肌损伤;炎症反应;肌卫星细胞;肌细胞外基质
【中图分类号】 R685 【文献标识码】 A 【文章编号】 1003—6350(2021)14—1877—04
Application of non-steroidal drugs in skeletal muscle injury.
LI Jian 1, JIANG Hua-sheng 1, TAN Rong-xiong 1, CAIJie-qin 1, WEI Bo 1, HUANG Chun-ming 2. 1. Guangdong Medical University, Zhanjiang 524000, Guangdong, CHINA;2. The People's Hospital of Gaozhou, Maoming 525000, Guangdong, CHINA【Abstract】 Skeletal muscle injury goes through a series of stages, including inflammation, regeneration, and fi-brosis. Inflammation causes pain, which reduces skeletal muscle function, and has a negative impact on motor perfor-mance. At present, Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used to reduce inflammation after skeletalmuscle injury, so as to alleviate pain and exercise skeletal muscle function in the early stage. However, whether the inter-vention of NSAIDS will disrupt the normal process of skeletal muscle injury repair, thus hindering the repair of skeletalmuscle injury. This review collects relevant literature to evaluate the effect of non-steroidal drugs in the treatment of skel-etal muscle injury, in order to provide relevant theoretical basis for clinical medication and guide treatment.
【Key words】 Nonsteroidal anti-inflammatory drugs (NSAIDs); Skeletal muscle injury; Inflammatory response;Muscle satellite cell; Extracellular matrix of muscle·综述·doi:10.3969/j.issn.1003-6350.2021.14.030
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