标题：阴道和宫腔微生物对健康与疾病的影响

      作者：舒思楠 1，叶红 1，刘程程 1，许梦梵 1，金淑文 1，蒲桃 2 综述 叶红 1 审校    1.三峡大学第一临床医学院妇产科，湖北 宜昌 443000；2.深圳市儿童医院，广东 深圳 518038

      卷次： 2021年32卷13期

      【摘要】 人类微生物组计划(human microbiome project，HMP)的研究突出了微生物群及其基因组在人类生态系统中的重要性，并强调了其对人类健康和疾病的重要作用。随着下一代测序(next-generation sequencing，NGS)技术在生殖道微生物的应用，其将有利于进一步发现微生物与宿主之间相互作用的功能和机制。然而与其他微生物群相比，生殖道微生物群研究未得到广泛的关注，但女性生殖道微生物又是一个影响生活质量及后代的领域，值得进行更深层次的研究。本文主要对阴道微生物、宫腔微生物和女性生殖道微生物对男性生殖道微生物群的影响进行综述。
      【关键词】 微生物群；妊娠；疾病；健康；女性
      【中图分类号】 R711.73 【文献标识码】 A 【文章编号】 1003—6350（2021）13—1747—05

Impact of vaginal and uterine microbes on health and disease.
SHU Si-nan 1, YE Hong 1, LIU Cheng-cheng 1, XUMeng-fan 1, JIN Shu-wen 1, PU Tao 2, YE Hong 1. 1. Department of Obstetrics and Gynecology, the First College of ClinicalMedical Science, China Three Gorges University, Yichang 443000, Hubei, CHINA; 2. Shenzhen Children's Hospital, Shenzhen518038, Guangdong, CHINA【Abstract】 The research of the human microbiome project (HMP) highlights the importance of the microbiomeand its genome in the human ecosystem, and emphasizes its important role in human health and disease. With the applica-tion of next-generation sequencing (NGS) technology in reproductive tract microorganisms, it will be helpful to furtherdiscover the functions and mechanisms of the interaction between microorganisms and hosts. However, compared withother microbiota, the research on the reproductive tract microbiota has not received extensive attention, but the female re-productive tract microbiota is an area that affects the quality of life and offspring, and it is worthy of further research.This article mainly reviews the effects of vaginal microbes, uterine microbes and female reproductive tract microbes onmale reproductive tract microbiota.
      【Key words】 Microbiota; Pregnancy; Disease; Health; Female·综述·doi:10.3969/j.issn.1003-6350.2021.13.033