标题：NLRP3炎症小体在缺血性脑损伤中作用的研究进展

      作者：田明巧，官劲帆，安露露 综述 韩江全 审校    遵义医科大学第五附属(珠海)医院神经内科，广东 珠海 519100

      卷次： 2021年32卷13期

      【摘要】 脑梗死是局部脑组织区域血液供应障碍，导致脑组织缺血缺氧性病变坏死，进而引起神经功能缺损的一种严重影响人类生命和生活质量的中枢神经系统疾病，因为其高发病率、致残率和致死率，为我国带来了沉重的经济负担和社会负担。炎症反应是缺血性脑损伤病理过程发生和发展的重要机制，核苷酸结合寡聚化结构域样受体蛋白3 (NLRP3)炎症小体通过促进白细胞介素1β (IL-1β)和白细胞介素18 (IL-18)的释放以及诱导细胞焦亡，在加剧脑梗死后缺血性脑损伤炎症反应过程中具有重要作用，通过研究调节NLRP3炎症小体的相关机制能为脑梗死的防治提供新的方向。
      【关键词】 NLRP3炎症小体；缺血性脑损伤；炎症反应；细胞焦亡；嘌呤能离子通道型7受体；丝裂原活化蛋白激酶；核因子E2 相关因子-2/抗氧化反应元件信号通路
      【中图分类号】 R651.1+5 【文献标识码】 A 【文章编号】 1003—6350（2021）13—1735—05

Research progress on the role of NLRP3 inflammasome in ischemic brain injury.
TIAN Ming-qiao, GUAN Jin-fan,An Lu-lu, HAN Jiang-quan. Department of Neurology, the Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University,Zhuhai 519100, Guangdong, CHINA【Abstract】 Cerebral infarction is a central nervous system disease that seriously affects human life and qualityof life, resulting in ischemic and oxygen-deficient lesion necrosis of brain tissue. Because of its high morbidity, disabilityand fatality rate, it has brought a heavy economic and social burden to our country. Inflammation is an important mecha-nism for the occurrence and development of the pathological process of ischemic brain injury. NLRP3 inflammatomeplays an important role in exacerbating the inflammatory response to ischemic brain injury after cerebral infarction bypromoting the release of IL-1β and IL-18 and inducing pyroptosis. The regulation of NLRP3 inflammalome mechanismcan provide a new direction for the prevention and treatment of cerebral infarction.
      【Key words】 NLRP3 inflammasome; Ischemic brain injury; Inflammation; Pyroptosis; Purinergic ligand-gatedion channel 7 receptor; Mitogen-activated protein kinase; Nrf2-ARE signaling pathway·综述·doi:10.3969/j.issn.1003-6350.2021.13.030基金项目：贵州省遵义市科技计划资助项目(编号：遵市科合社字[2018]20号)