标题：长链非编码RNA与心血管疾病关系的研究进展

      作者：张媛 1 综述 徐明国 2 审校    1.汕头大学医学院，广东 汕头 515000；2.深圳市儿童医院，广东 深圳 518000

      卷次： 2021年32卷13期

      【摘要】 长链非编码RNA (long non-coding RNA，LncRNA)是一类由两百至十万个核苷酸组成却不参与蛋白质编码的RNA序列，研究者最初认为LncRNA是RNA聚合酶Ⅱ的副产物，不具备生物活性。但近年来大量研究发现，LncRNA可在多层面上(表观遗传调控、转录调控以及转录后调控等)对基因表达进行调控。通过参与细胞分化、增殖、凋亡和自噬等环节，影响多种心血管疾病的发生、进展。LncRNA有望成为疾病诊断或药物研发的新靶点。本文综述了LncRNA与常见心血管疾病之间的关系，以期为后续心血管疾病的诊断和治疗提供理论基础。
      【关键词】 长链非编码RNA；基因表达；调控；心血管疾病；药物研发；新靶点
      【中图分类号】 R54 【文献标识码】 A 【文章编号】 1003—6350（2021）13—1731—04

New progress in the role of long non-coding RNA in cardiovascular disease.
ZHANG Yuan 1, XU Ming-guo 2.1. Medical College, Shantou University, Shantuo 515000, Guangdong, CHINA; 2. Shenzhen Children's Hospital, Shenzhen518000, Guangdong, CHINA【Abstract】 Long non-coding RNA (LncRNA) is a type of RNA sequence composed of two hundred to one hun-dred thousand nucleotides but not involved in protein coding. Researchers initially believed that LncRNA was a by-prod-uct of RNA polymerase Ⅱ, did not have biological activity. However, in recent years, a large number of studies havefound that LncRNA can regulate gene expression on multiple levels (epigenetic regulation, transcription regulation,post-transcriptional regulation, etc.). By participating in cell differentiation, proliferation, apoptosis and autophagy, it af-fects the occurrence and progress of a variety of cardiovascular diseases. LncRNA is expected to become a new target fordisease diagnosis or drug development. This article reviews the relationship between LncRNA and common cardiovasculardiseases, in order to provide a theoretical basis for subsequent diagnosis and treatment of cardiovascular diseases.
      【Key words】 Long non-coding RNA (LncRNA); Gene expression; Regulation; Cardiovascular disease; Drug de-velopment; New targets·综述·doi:10.3969/j.issn.1003-6350.2021.13.029基金项目：国家自然科学基金(编号：81870364）；广东省深圳市三名工程项目(编号：SZSM20162057）