标题：CA125、HE4及LIMK2在不同级别浆液性卵巢癌血清和组织中的表达及临床意义

      作者：杨雨晴 1，石小青 1，时春丽 2    湖南省妇幼保健院妇产科 1、病理科 2，湖南 长沙 410000

      卷次： 2021年32卷13期

      【摘要】 目的 检测糖类抗原 125 (CA125)、人附睾蛋白 4 (HE4)和LIM激酶 2 (LIMK2)在低、高级别浆液性卵巢癌血清和病理组织中的表达水平，并探讨其临床意义。方法 回顾性分析湖南省妇幼保健院 2018年 1月至 2020年 6月期间收治的 103例浆液性卵巢癌患者的临床资料，将其分为低级别浆液性卵巢癌 33例和高级别浆液性卵巢癌70例，检测并比较不同级别浆液性卵巢癌患者血清和病理组织中的CA125、HE4及LIMK2蛋白的表达差异。结果 高级别浆液性卵巢癌患者的血清CA125、HE4水平分别为(663.27±112.09) U/mL、(431.77±69.57) pmol/L，明显高于低级别浆液性卵巢癌的(488.34±100.11) U/mL、(302.15±60.32) pmol/L，差异均有统计学意义(P<0.05)；高级别浆液性卵巢癌患者的病理组织中HE4、LIMK2蛋白表达的阳性率分别为97.14%和100.00%，明显高于低级别浆液性卵巢癌患者的27.27%和15.15%，差异均有统计学意义(P<0.05)。结论 CA125、HE4及LIMK2蛋白在高级别浆液性卵巢癌血清和病理组织的表达水平明显高于低级别浆液性卵巢癌，可以为临床诊疗工作提供鉴别依据。
      【关键词】 低级别浆液性卵巢癌；高级别浆液性卵巢癌；糖类抗原125；人附睾蛋白4；LIM激酶2；病理
      【中图分类号】 R737.31 【文献标识码】 A 【文章编号】 1003—6350（2021）13—1725—03

Expression of CA125, HE4, and LIMK2 in serum and tissues of serous ovarian cancer of different grades.
YANGYu-qing 1, SHI Xiao-qing 1, SHI Chun-li 2. Department of Obstetrics and Gynecology 1, Department of Pathology 2, HunanMaternal and Child Health Hospital, Changsha 410000, Hunan, CHINA
【Abstract】 Objective To investigate the differences in the expression of carbohydrate antigen 125 (CA125), hu-man epididymal protein 4 (HE4), and LIM kinase 2 (LIMK2) in serum and pathological tissues of low and high grade se-rous ovarian cancer and its clinical significance. Methods The clinical data of 103 patients with serous ovarian cancer ad-mitted to Hunan Maternal and Child Health Hospital from January 2018 to June 2020 were retrospectively analyzed. Theywere divided into low-grade serous ovarian cancer (33 cases) and high-grade serous ovarian cancer (70 cases). The expres-sion differences of CA125, HE4, and LIMK2 in serum and pathological tissue of patients with serous ovarian cancer of dif-ferent grades were compared. Results The serum levels of CA125 and HE4 were (663.27±112.09) U/mL and (431.77±69.57) pmol/L in high-grade serous ovarian cancer patients, respectively, significantly higher than (488.34±100.11) U/mLand (302.15±60.32) pmol/L in low-grade serous ovarian cancer (P<0.05). The positive rates of HE4 and LIMK2 proteinexpression in high-grade serous ovarian cancer patients were 97.14% and 100.00%, respectively, which were significantlyhigher than 27.27% and 15.15% in low-grade serous ovarian cancer patients (P<0.05). Conclusion The levels of CA125,HE4, and LIMK2 in serum and pathological tissue of high-grade serous ovarian cancer are significantly higher than thosein low-grade serous ovarian cancer, which can provide a basis for clinical diagnosis and treatment.
      【Key words】 Low-grade serous ovarian cancer; High-grade serous ovarian cancer; Carbohydrate antigen 125;Human epididymal protein 4; LIM kinase 2; Pathology·短篇论著·doi:10.3969/j.issn.1003-6350.2021.13.027