标题：不同孕期孕妇外周血钙、锌、铁元素含量的变化及临床意义

      作者：杨凯芬，蔡惠苗，敖银柳    东莞市长安镇医院妇产科，广东 东莞 523843

      卷次： 2021年32卷13期

      【摘要】 目的 观察不同孕期孕妇外周血钙、锌、铁元素含量的变化，并探讨其临床意义。方法 回顾性分析2019年 1月至 2020年 12月在东莞市长安镇医院建册、检查及分娩的 300例孕妇的临床资料，其中 218例在孕期自愿接受按计划增补钙、锌、铁营养元素的孕妇纳入干预组，82例在孕期拒绝接受增补钙、锌、铁营养元素，仅饮食补充营养的孕妇纳入对照组。比较两组孕妇不同孕期的外周血钙、锌、铁含量，妊娠合并症，分娩方式和新生儿生育指标。结果 干预组孕妇孕中期外周血钙、锌、铁含量分别为(1.49±0.19) mmol/L、(124.39±14.28) μmol/L、(7.34±0.85) mmol/L，明显高于对照组的(1.32±0.14) mmol/L、(115.49±11.05) μmol/L、(7.06±0.76) mmol/L，差异均有统计学意义(P<0.05)；干预组孕妇孕晚期外周血钙、锌、铁含量分别为(1.35±0.13) mmol/L、(117.94±12.94) μmol/L、(7.06±0.75) mmol/L，明显高于对照组的(1.20±0.10) mmol/L、(110.05±10.13) μmol/L、(6.71±0.63) mmol/L，差异均有统计学意义(P<0.05)；干预组孕妇妊娠合并症总发生率和剖宫产率分别为 2.29%、12.84%，明显低于对照组的8.54%、24.39%，差异均有统计学意义(P<0.05)；干预组新生儿的体质量、身长、头围、胸围明显大(重)于对照组，差异均有统计学意义(P<0.05)。结论 孕妇外周血钙、锌、铁元素含量对妊娠结局和胎儿发育质量有一定影响，临床应加强孕期对钙、锌、铁的补充，满足孕期营养元素钙、锌、铁的需求。
      【关键词】 妊娠期；营养元素；钙；锌；铁；妊娠结局
      【中图分类号】 R714.14 【文献标识码】 A 【文章编号】 1003—6350（2021）13—1692—03

Changes and clinical significance of calcium, zinc, and iron in peripheral blood of pregnant women duringdifferent pregnancy.
YANG Kai-fen, CAI Hui-miao, AO Yin-liu. Department of Obstetrics and Gynecology, Chang'anTown Hospital of Dongguan City, Dongguan 523843, Guangdong, CHINA
【Abstract】 Objective To observe the changes of calcium, zinc, and iron in peripheral blood of pregnant wom-en during different pregnancy, and explore its clinical significance. Methods The clinical data of 300 pregnant womenwho were registered, examined and delivered in Chang 'an Town Hospital of Dongguan City from January 2019 to De-cember 2020 were analyzed retrospectively. Among them, 218 pregnant women who voluntarily received calcium, zincand iron supplements during pregnancy were included in the intervention group, and 82 pregnant women who refused toreceive calcium, zinc and iron supplements during pregnancy were included in the control group. The contents of calcium,zinc and iron in peripheral blood, pregnancy complications, delivery mode and neonatal fertility indexes between the twogroups were compared. Results The contents of calcium, zinc, and iron in the peripheral blood of pregnant women in thesecond trimester of pregnancy in the intervention group were respectively (1.49±0.19) mmol/L, (124.39±14.28) μmol/L ,and (7.34±0.85) mmol/L, which were significantly higher than (1.32±0.14) mmol/L, (115.49±11.05) μmol/L, and (7.06±0.76) mmol/L of the control group (P<0.05). The contents of calcium, zinc, and iron in the peripheral blood of pregnantwomen in the later trimester of pregnancy in the intervention group were respectively (1.35±0.13) mmol/L, (117.94±12.94) μmol/L, and (7.06±0.75) mmol/L, which were significantly higher than (1.20±0.10) mmol/L, (110.05±10.13) μmol/Land (6.71±0.63) mmol/L of the control group (P<0.05). The total incidence of pregnancy complications and cesarean sec-tion in the intervention group were 2.29% and 12.84% , respectively, which were significantly lower than 8.54% and24.39% in the control group (P<0.05). The weight, length, head circumference, and chest circumference of newborns inthe intervention group were significantly larger than those in the control group, and the differences were statistically sig-nificant (P<0.05). Conclusion The content of calcium, zinc, and iron in pregnant women's peripheral blood has certaininfluence on pregnancy outcome and fetal development quality. It is necessary to strengthen the supplement of calcium,zinc, and iron during pregnancy to meet the demand of nutritional elements calcium, zinc and iron during pregnancy.
      【Key words】 Pregnancy; Trace elements; Calcium; Zinc; Iron; Pregnancy outcome