标题：加味二仙汤治疗围绝经期高血压冲任失调证的疗效及对患者神经递质和性激素的影响

      作者：范舜华 1，罗艳芳 2，陈浩生 1，罗捷玲 2    佛山市中医院三水医院心血管专科 1、妇科 2，广东 佛山 528100

      卷次： 2021年32卷13期

      【摘要】 目的 观察加味二仙汤治疗围绝经期高血压冲任失调症的疗效，并探讨其对患者神经递质和性激素的影响。方法 选择2019年2月至2020年1月佛山市中医院三水医院收治的80例围绝经期高血压冲任失调症患者作为研究对象。采用随机数表法分观察组和对照组，每组40例。两组患者均接受尼群地平口服治疗，对照组同时给予贝那普利治疗，观察组在对照组治疗基础上联合加味二仙汤治疗。治疗8周后，比较两组患者的治疗效果，以及治疗前后的血压、任失调证评分、Kupperman评分、神经递质[血浆神经肽Y (NPY)、神经降压素(NT)]及性激素[血清雌二醇(E2)、睾酮(T)、孕酮(P)、性激素结合蛋白(SHGB)]水平，同时比较两组患者治疗期间的不良反应情况。结果 观察组患者的治疗总有效率为95.0%，明显高于对照组的80.0%，差异有统计学意义(P<0.05)；治疗后，两组患者的舒张压(DBP)、收缩压(SBP)均下降，且观察组[(113.32±9.11) mmHg、(71.12±6.11) mmHg]明显低于对照组[(125.13±10.33) mmHg、(76.29±5.61) mmHg]，差异均有统计学意义(P<0.05)；治疗后，两组患者的冲任失调证评分、Kupperman评分均降低，且观察组[(9.13±2.11)分、(6.78±1.01)分]明显低于对照组[(15.12±3.02)分、(10.13±2.21)分]，差异均有统计学意义(P<0.05)；治疗后，两组患者的NPY、NT均降低，且观察组[(96.13±7.13) ng/L、(51.17±8.14) ng/L]明显低于对照组[(105.18±8.02) ng/L、(62.36±7.11) ng/L]，差异均有统计学意义(P<0.05)；治疗后，两组患者的P、T水平均降低，且观察组[(3.99±0.79) pmol/L、(1.67±0.31) nmol/L]明显低于对照组[(4.62±1.02) pmol/L、(2.68±0.52) nmol/L]，E2、SHGB水平均升高，且观察组[(65.13±7.11) pmol/L、(48.46±5.11) nmol/L]明显高于对照组[(54.89±6.22) pmol/L、(42.12±6.23) nmol/L]，差异均有统计学意义(P<0.05)。结论 加味二仙汤治疗围绝经期高血压冲任失调证能有效改善患者的临床症状，调节神经递质和性激素水平，临床治疗效果较好。
      【关键词】 高血压；冲任失调证；加味二仙汤；神经递质；性激素
      【中图分类号】 R544.1 【文献标识码】 A 【文章编号】 1003—6350（2021）13—1655—04

Curative effect of modified Erxian Decoction in treating perimenopausal hypertension with Chong Ren disordersyndrome and its influence on neurotransmitters and sex hormones.
FAN Shun-hua 1, LUO Yan-fang 2, CHENHao-sheng 1, LUO Jie-ling 2. Cardiovascular Department 1, Department of Gynecology 2, Sanshui Hospital, Foshan Hospitalof Traditional Chinese Medicine, Foshan 528100, Guangdong, CHINA
【Abstract】 Objective To observe the curative effect of modified Erxian Decoction in the treatment of peri-menopausal hypertension with Chong Ren disorder, and to explore its influence on neurotransmitters and sex hormones.Methods Eighty patients of perimenopausal hypertension with Chong Ren disorder in Sanshui Hospital of Foshan Tra-ditional Chinese Medicine from February 2019 to January 2020 were selected as the research objects. They were random-ly divided into an observation group and a control group, with 40 patients in each group. Plus nitrendipine oral treatment,patients in the control group was given benazepril treatment, and patients in the observation group were treated withmodified Erxian Decoction on the basis of the control group. After 8 weeks of treatment, the treatment effect, blood pres-sure, Ren maladjustment syndrome score, Kupperman score, neurotransmitter (plasma neuropeptide Y [NPY], neuroten-sin [NT]), and sex hormone (serum estradiol [E2], testosterone [T], progesterone [P], sex hormone binding protein[SHGB]) levels before and after treatment were compared between the two groups, and the adverse reactions during treat-ment were compared between the two groups situation. Results The total effective rate of the observation group(95.0%) was significantly higher than that of the control group (80.0%), and the difference was statistically significant(P<0.05). After treatment, the diastolic blood pressure (SBP) and systolic blood pressure (DBP) of the two groups of pa-tients decreased, and the levels in the observation group were (113.32±9.11) mmHg, 71.12±6.11) mmHg, significantlylower than (125.13 ± 10.33) mmHg, (76.29 ± 5.61) mmHg in the control group (P<0.05); after treatment, the scores ofChong Ren disorder syndrome and Kupperman scores of the two groups decreased, and the scores in the observationgroup were (9.13±2.11) points, (6.78±1.01) points, significantly lower than (15.12±3.02) points, (10.13±2.21) points inthe control group (P<0.05); after treatment, NPY and NT of the two groups were decreased, and the levels in the observa-