标题：Ⅲ~Ⅴ期慢性肾病患者贫血的危险因素分析

      作者：胡显芳
    (重庆市涪陵区人民医院内一科，重庆 408000)

      卷次： 2014年25卷12期

      【摘要】 目的 调查Ⅲ~Ⅴ期慢性肾病（CKD）患者贫血的发生率及相关危险因素。方法 随机选择我院
2010年2月至2013年2月诊断为慢性肾脏病并肾小球滤过率低于60 ml/min患者218例，分析患者临床资料及其
与贫血发生的相关性。结果 Ⅲ~Ⅴ期慢性肾病患者中贫血发生率分别为49.2%、82.9%和95.6%。透析患者的
贫血发生率(95.9%)较非透析患者（66.9%）高，差异有统计学意义(P<0.05)。单因素分析显示年龄、CKD分期、是
否透析、白蛋白及血钙水平、体重指数、尿渗透浓度、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、血清EPO水平与贫血
的发生率有关(P<0.05)；多因素Logistic回归分析显示仅CKD分期、白蛋白及血钙水平与贫血的发生显著相关
(P<0.05)。结论 CKD分期晚、白蛋白及血钙水平低是Ⅲ ~Ⅴ期慢性肾病患者发生贫血的相关危险因素。

      【关键词】 慢性肾脏病；贫血；危险因素

      【中图分类号】 R692 【文献标识码】 A 【文章编号】 1003—6350（2014）12—1739—03


Analysis of risk factors for anemia in patients with phase Ⅲ to Ⅴ chronic kidney disease.
HU Xian-fang. The
First Department of Internal Medicine, the People's Hosipital of Fuling District, Chongqing 408000, CHINA

【Abstract】 Objective To investigate the prevalence and risk factors of anemia in the patients with phaseⅢ
toⅤ chronic kidney disease (CKD). Methods 218 patients diagnosed as CKD with glomerular filtration rate < 60ml/
min were collected in our hospital from February 2010 to February 2013. The association between clinical data and
anemia occurrence was analysed. Results The prevalences of anemia in patients with phase Ⅲ ~Ⅴ CKD were
49.2%, 82.9% and 95.6%, respectively. The prevalence of anemia in dialysis patients and non-dialysis patients were
95.9% and 66.9% (P<0.05). Univariate analysis indicated that age, CKD phase, dialysis, albumin and blood calcium
levels, body mass index, urine osmotic concentration, N-acetyl-β-D-glucosaminidase (NAG) and serum erythropoie-
tin (EPO) levels were related to the occurrence of anemia (P<0.05). Multivariate logistic regression analysis indicated
that only CKD phase, albumin and calcium levels were significantly related with anemia (P<0.05). Conclusions Ad-
vanced CKD phase, low albumin and calcium levels were risk factors of anemia in patients with phaseⅢ~Ⅴ CKD.

      【Key words】 Chronic kidney disease; Anemia; Risk factors
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