标题：痛风石的治疗新进展

      作者：郭正东 1，2，3 综述 郑林洋 1，陈东 1，吴乾锦 1，杨健 1，彭磊 1，2，3 审校    1.海南医学院第一附属医院创伤医学中心，海南 海口 570216；2.海南医学院急救与创伤研究教育部重点实验室，海南 海口 571199；3.海南医学院第一附属医院创伤与灾难救援研究重点实验室，海南 海口 570102

      卷次： 2021年32卷7期

      【摘要】 痛风石是慢性痛风的特征性临床表现，其可以造成关节畸形、活动受限、皮肤破溃和感染等，还会增加患者的心理负担。痛风石一旦破溃感染后，其治疗周期长、愈合较慢，且需多次手术治疗，效果欠佳，是创伤骨科医师所面临的临床难题。近年来，随着多学科的联合治疗和新技术的发展，在治疗痛风石方面的手段也日益增多，提高了治愈率，本文就痛风石的治疗做一综述。
      【关键词】 痛风；痛风石；药物疗法；尿酸；外科疗法；创面修复
      【中图分类号】 R589.7 【文献标识码】 A 【文章编号】 1003—6350（2021）07—0921—03

Progress in the treatment of tophus.
GUO Zheng-dong 1,2,3, ZHENG Lin-yang 1, CHEN Dong 1, WU Qian-jin 1, YANGJian 1, PENG Lei 1,2,3. 1. Trauma Medical Center, the First Affiliated Hospital of Hainan Medical College, Haikou 570216,Hainan, CHINA; 2. Key Laboratory of Emergency and Trauma Ministry of Education, Hainan Medical University, Haikou571199, Hainan, CHINA; 3. Key Laboratory of Hainan Trauma and Disaster Rescue, the First Affiliated Hospital of HainanMedical University, Haikou 570102, Hainan, CHINA【Abstract】 Tophus is the characteristic clinical manifestation of chronic gout, which can cause joint deformity,movement limitation, skin ulceration and infection, and increase the psychological burden of patients. Once the tophus isulcerated and infected, it requires long, healing is slow, and multiple surgical treatments, and the heading is slow and theeffect is not good. This has become a clinical problem faced by orthopedic trauma surgeons. In recent years, with the de-velopment of multidisciplinary combined therapy and new technologies, the methods for treating tophus have been in-creasing, which has increased the cure rate. This paper reviews the treatment of tophus.
      【Key words】 Gout; Tophus; Pharmacotherapy; Uric acid; Surgical treatment; Wound healing·综述·doi:10.3969/j.issn.1003-6350.2021.07.027基金项目：国家自然科学基金(编号：81460339)