标题：内皮细胞膜微粒与缺血性脑卒中的相关性研究进展

      作者：朱良琴，张惠婷，叶烨 综述 钟望涛，马晓瑭 审校    广东医科大学附属医院神经内科，广东 湛江 524000

      卷次： 2021年32卷7期

      【摘要】 脑卒中是全球成年人致残的首要原因，其中缺血性脑卒中(IS)占脑卒中病例的80%以上。内皮细胞膜微粒(EMVs)是内皮细胞(ECs)活化或凋亡时从其表面释放的小囊泡。近年来多项研究发现EMVs在 IS的发生发展过程中扮演着重要角色。本综述将阐述和总结EMVs生物学特性及其在 IS临床诊疗中的潜在临床价值。
      【关键词】 缺血性脑卒中；内皮细胞膜微粒；内皮细胞；生物学特性；生物学标志物；治疗
      【中图分类号】 R743.3 【文献标识码】 A 【文章编号】 1003—6350（2021）07—0904—05

Research progress on the relationship between endothelial microvesicles and ischemic stroke.
ZHU Liang-qin,ZHANG Hui-ting, YE Ye, ZHONG Wang-tao, MA Xiao-tang. Department of Neurology, the Affiliated Hospital ofGuangdong Medical University, Zhanjiang 524000, Guangdong, CHINA【Abstract】 Stroke is the leading cause of adult disability in the world, and ischemic stroke (IS) accounts formore than 80% of stroke cases. Endothelial microvesicles (EMVs) are small vesicles released from the surface of endo-thelial cells (ECs) during activation or apoptosis. In recent years, many studies have found that EMVs play an importantrole in the development of ischemic stroke. This article will elaborate and summarize the biological characteristics ofEMVs and their potential clinical value in the clinical diagnosis and treatment of ischemic stroke.
      【Key words】 Ischemic stroke; Endothelial microvesicles (EMVs); Endothelial cells; Biological characteristics;Biological marker; Treatment·综述·doi:10.3969/j.issn.1003-6350.2021.07.023