标题：Gremlin促血管生成作用的研究进展

      作者：谢宇欣 综述 石国庆 审校    遵义医科大学附属医院，贵州 遵义 563000

      卷次： 2021年32卷7期

      【摘要】 Gremlin是半胱氨酸结超家族的成员，在发育过程中通过抑制骨形态形成蛋白(BMP)途径发挥作用，属于BMP拮抗剂。然而，Gremlin还有一些与BMP信号通路无关的功能。近年来的研究发现，Gremlin还是一种新型的VEGFR2激动剂，与血管生成相关性疾病有关。因此，Gremlin作为一种新型促血管生成因子，Gremlin-VEG-FR2是血管生成的非经典途径信号通路。本文就Gremlin通过VEGFR2途径促血管生成作用在相关疾病中的研究进展做一综述。
      【关键词】 Gremlin；VEGFR2；新型VEGFR2激动剂；非经典途径信号通路；血管生成
      【中图分类号】 R543 【文献标识码】 A 【文章编号】 1003—6350（2021）07—0899—05

Research progress on the role of Gremlin in promoting angiogenesis.
XIE Yu-xin, SHI Guo-qing. The AffiliatedHospital of Zunyi Medical University, Zunyi 563000, Guizhou, CHINA【Abstract】 Gremlin, a member of the cysteine knot superfamily, is a bone morphogenetic protein (BMP) antago-nist that plays a role in the development process by inhibiting BMP pathway. However, Gremlin also has some functionsthat are independent of BMP signaling pathway. In recent years, Gremlin has been found to be a novel VEGFR2 agonistassociated with angiogenesis-related diseases. Therefore, Gremlin is a novel pro-angiogenic factor, and Gremlin-VEG-FR2 is a non-classical signaling pathway for angiogenesis. This article reviews Gremlin's role in promoting angiogenesisthrough VEGFR2 pathway in related diseases.
      【Key words】 Gremlin; VEGFR2; Novel VEGFR2 agonist; Non-classical pathway; Angiogenesis·综述·doi:10.3969/j.issn.1003-6350.2021.07.022基金项目：贵州省遵义市联合基金项目[编号：遵市科合社字(2018)99]