标题：盐酸米诺环素软膏联合布洛芬治疗老年人慢性牙周炎的疗效及对患者炎性因子的影响

      作者：冉碧红 1，龙晓玲 2，冉萌 3    1.汉中市汉台区妇幼保健院口腔科，陕西 汉中 723000；2.汉中市职业技术学院附属医院口腔科，陕西 汉中 723000；3.西安医学院附属汉江医院检验科，陕西 西安 723000

      卷次： 2021年32卷7期

      【摘要】 目的 研究盐酸米诺环素软膏联合布洛芬治疗老年人慢性牙周炎的疗效及对患者炎症应激状况的影响。方法 选取2014年1月至2018年12月在汉中市汉台区妇幼保健院口腔门诊就诊的60例老年慢性牙周炎患者作为研究对象。按照随机数表法将其分为观察组和对照组各30例。对照组患者采用盐酸米诺环素软膏治疗，观察组患者在对照组治疗的基础上采用布洛芬治疗，于治疗前和治疗4周后记录并比较两组患者的菌斑指数(PLI)、龈沟出血指数(SBI)和牙周袋深度(PD)、牙龈指数(GI)、牙齿松动度(TM)、牙周附着丧失(AL)等牙周指标值，超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α (TNF-α)及白介素-6 (IL-6)等炎性因子指标值以及治疗效果和治疗后不良反应发生情况。结果 观察组患者的治疗总有效率为96.7%，明显高于对照组的70.0%，差异有统计学意义(P<0.05)；治疗前，两组患者的PLI、SBI、PD牙周指标值比较差异均无统计学意义(P>0.05)，治疗后，两组患者的上述各项指标值均明显降低，且观察组患者的PLI、SBI、PD分别为(0.79±0.24)分、(1.26±0.43)分、(2.43±0.31) mm，明显低于对照组的(1.21±0.31)分、(1.87±0.64)分、(3.12±0.46) mm，差异均有统计学意义(P<0.05)；治疗前，两组患者的hs-CRP、TNF-α、IL-6水平比较，差异均无统计学意义(P>0.05)，治疗后，两组患者的上述各项指标均明显下降，且观察组患者的hs-CRP、TNF-α、IL-6水平分别为(4.87±1.21) mg/L、(3.16±0.69) ng/L、(18.43±2.01) ng/mL，明显低于对照组的(7.54±2.06) mg/L、(4.37±0.75) ng/L、(21.67±3.63) ng/mL，差异均有统计学意义(P<0.05)；观察组患者治疗后的不良反应总发生率为3.3%，明显低于对照组的26.7%，差异有统计学意义(P<0.05)。结论 盐酸米诺环素软膏联合布洛芬治疗老年人慢性牙周炎能显著改善慢性牙周炎的临床症状，控制牙周炎症，减少组织破坏，缓解机体炎性应激反应，不良反应较少，具有临床应用价值。
      【关键词】 慢性牙周炎；老年；盐酸米诺环素软膏；布洛芬；疗效；炎症应激
      【中图分类号】 R781.4 【文献标识码】 A 【文章编号】 1003—6350（2021）07—0881—04

Effect of minocycline hydrochloride ointment combined with ibuprofen in the treatment of elderly patients withchronic periodontitis and its influence on inflammatory factors.
RAN Bi-hong 1, LONG Xiao-ling 2, RAN Meng 3. 1.Department of Stomatology, Maternal and Child Health Hospital of Hantai District, Hanzhong 723000, Shaanxi, CHINA; 2.Department of Stomatology, the Affiliated Hospital of Hanzhong Vocational and Technical College, Hanzhong 723000,Shaanxi, CHINA; 3. Department of Clinical Laboratory, Hanjiang Hospital Affiliated to Xi'an Medical College, Xi’an723000, Shaanxi, CHINA
【Abstract】 Objective To study the effect of minocycline hydrochloride ointment combined with ibuprofen inthe treatment of elderly patients with chronic periodontitis and its influence on inflammatory stress. Methods FromJanuary 2014 to December 2018, 60 elderly patients with chronic periodontitis were selected as the research objects. Thepatients were divided into the study group and control group (with 30 cases in each group) according to random numbertable method. The control group was treated with minocycline hydrochloride ointment, and the study group was treatedwith ibuprofen on the basis of the control group. Before treatment and 4 weeks after treatment, the periodontal indexessuch as plaque index (PLI), gingival sulcus bleeding index (SBI) and periodontal pocket depth (PD), gingival index (GI),degree of loose teeth (TM), periodontal attachment loss (AL) of the two groups were recorded and compared. Inflamma-tory factor index including hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α) and inter-leukin 6 (IL-6), and adverse reactions before and after the treatment were also compared. Results The total effectiverate of the study group was 96.7%, which was significantly higher than 70.0% of the control group (P<0.05); before thetreatment, there was no statistically significant difference in the PLI, SBI, PD periodontal indexes (all P>0.05); aftertreatment, the above-mentioned indexes of two groups were significantly decreased, and PLI SBI, PD in the study groupwere (0.79±0.24) points, (1.26±0.43) points, (2.43±0.31) mm, respectively, which were significantly lower than corre-