标题：帕金森病伴抑郁的发病机制及治疗进展

      作者：范少凯，李炳翰，韩博雅 综述 刘斌 审校    华北理工大学附属医院神经内一科，河北 唐山 063000

      卷次： 2021年32卷6期

      【摘要】 帕金森病伴发抑郁是帕金森病一种常见的非运动症状，目前在国内并没有得到过多关注，因此耽误了治疗的最佳时期。帕金森病伴发抑郁导致患者的生活质量受到影响，严重的情况可导致患者运动障碍、认知障碍等情况加重，给家庭与社会造成很大的压力。解剖、代谢和功能影像学在发展，临床对该疾病的发生发展的相关机制以及诊治方法都有了深层的理解。本文着重对帕金森病伴发抑郁的发病机制和诊治方法展开综述，希望可以为今后的临床治疗工作给予指导建议。
      【关键词】 帕金森病；非运动症状；抑郁；发病机制；治疗；综述
      【中图分类号】 R742.5 【文献标识码】 A 【文章编号】 1003—6350（2021）06—0770—04

Progress in pathogenesis and treatment of depression in Parkinson's disease.
FAN Shao-kai, LI Bing-han, HANBo-ya, LIU Bin. Department of Neurology, the Affiliated Hospital of North China University of Science and Technology,Tangshan 063000, Hebei, CHINA【Abstract】 Depression in Parkinson's disease is a common non-motor symptom of Parkinson's disease. As thedisease has not received much attention in China, the patients often miss the optimal treatment period. Parkinson's dis-ease is associated with depression, which affects the patient's quality of life. In severe cases, the patient may suffer frommotor disorders, cognitive disorders and other aggravations, causing great stress to the family and society. With the devel-opment of anatomy, metabolism and functional imaging, we have a deep understanding of the pathogenesis, diagnosisand treatment of this disease. This article focuses on the pathogenesis, diagnosis and treatment of Parkinson's disease ac-companied by depression, hoping to provide guidance and suggestions for future clinical treatment.
      【Key words】 Parkinson's disease; Non-motor symptoms; Depression; Pathogenesis; Treatment; Review·综述·25doi:10.3969/j.issn.1003-6350.2021.06.025基金项目：2019年河北省政府资助临床医学优秀人才培养项目计划(编号：2019【46】)