标题：结直肠癌的治疗：以肿瘤相关巨噬细胞为靶点的新观点

      作者：魏颖婷 综述 赵逵 审校    遵义医科大学附属医院消化内科，贵州 遵义 563000

      卷次： 2021年32卷6期

      【摘要】 肿瘤相关巨噬细胞(TAM)具有其独特的可塑性，在肿瘤微环境中存在的生长因子和趋化因子作用下，可以极化成不同功能的巨噬细胞亚群。其中M1巨噬细胞主要在抵抗病原体感染、促进炎症和抑制肿瘤中发挥重要作用，M2巨噬细胞主要在组织修复、免疫抑制和促进肿瘤进展中发挥作用。因此，通过靶向调控TAM可能为治疗结直肠癌提供新的免疫治疗思路。
      【关键词】 结直肠癌；肿瘤微环境；肿瘤相关巨噬细胞；可塑性；靶向调控；免疫治疗
      【中图分类号】 R735 【文献标识码】 A 【文章编号】 1003—6350（2021）06—0766—04

Treatment of colorectal cancer: a new viewpoint of targeting tumor-associated macrophage therapy.
WEIYing-ting, ZHAO Kui. Department of Gastroenterology, the Affiliated Hospital of Zunyi Medical University, Zunyi 563000,Guizhou, CHINA【Abstract】 Tumor-associated macrophage (TAM) has its unique plasticity and can be polarized into macrophagesubsets with different functions under the action of growth factors and chemokines in tumor microenvironment. M1 mac-rophages mainly play an important role in resisting pathogen infection, promoting inflammation and inhibiting tumor,while M2 macrophages mainly play a role in tissue repair, immunosuppression and promoting tumor progression. There-fore, targeted regulation of TAM may provide a new idea of immunotherapy for the treatment of colorectal cancer.
      【Key words】 Colorectal cancer; Tumor microenvironment; Tumor-associated macrophages; Plasticity; Targetedregulation; Immunotherapy·综述·doi:10.3969/j.issn.1003-6350.2021.06.024基金项目：国家自然科学基金(编号：81560467)