标题：桃红四物汤用于甲状腺术后快速康复的临床疗效观察

      作者：李娟，朱卫洲，邓谊针，赵树文    清远市中医院普外科，广东 清远 511500

      卷次： 2021年32卷5期

      【摘要】 目的 观察桃红四物汤用于甲状腺术后快速康复的临床疗效。方法 选择2017年7月1日至2020年6月30日在清远市中医院普外科接受甲状腺手术的80例患者进行研究，按随机数表法将患者分为观察组和对照组，每组40例。对照组患者术后给予左甲状素钠片口服治疗，观察组患者在对照组治疗的基础上联合桃红四物汤治疗，两组患者均用药15 d。比较两组患者的临床疗效，手术前后的游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和血小板计数水平及不良反应。结果 治疗15 d后，观察组患者的治疗总有效率为95.0%，明显高于对照组的85.0%，差异有统计学意义(P<0.05)；治疗后，观察组患者的 FT3、FT4、TSH水平分别为(3.23±0.35) pmol/L，(13.53±2.70) pmol/L，(6.02±1.35) μIU/mL，对照组分别为(2.90±0.44) pmol/L，(11.26±2.68) pmol/L，(7.67±1.42) μIU/mL，观察组患者的FT4水平明显高于对照组，TSH水平明显低于对照组，差异均有统计学意义(P<0.05)，而两组患者的FT3水平比较差异无统计学意义(P>0.05)；观察组患者的TT、PT、APTT、FIB、血小板计数分别为(20.30±1.56) s、(11.69±0.51) s、(36.75±2.04) s、(7.23±0.36) g/L、(320.71±31.50)×109/L，对照组分别为(22.74±2.12) s、(13.07±0.43) s、(38.52±2.15) s、(8.80±0.53) g/L、(372.14±29.34)×109/L，观察组患者的上述各项指标明显低于对照组，差异均有统计学意义(P<0.05)；治疗过程中，观察组患者的不良反应发生率为5.0%，明显低于对照组的12.5%，差异有统计学意义(P<0.05)。结论 甲状腺手术后患者应用桃红四物汤能有效改善患者的甲状腺功能及凝血功能各项指标，值得临床推广应用。
      【关键词】 桃红四物汤；甲状腺术后；临床疗效；甲状腺功能；凝血功能
      【中图分类号】 R653 【文献标识码】 A 【文章编号】 1003—6350（2021）05—0614—03

Clinical effect of Taohong Siwu Decoction for rapid rehabilitation after thyroid surgery.
LI Juan, ZHU Wei-zhou,DENG Yi-zhen, ZHAO Shu-wen. Department of General Surgery, Qingyuan Hospital of Traditional Chinese Medicine,Qingyuan 511500, Guangdong, CHINA
【Abstract】 Objective To study the clinical observation of Taohong Siwu Decoction for rapid rehabilitation af-ter thyroid surgery. Methods A total of 80 patients with thyroid surgery, who admitted to Department of General Sur-gery, Qingyuan Hospital of Traditional Chinese Medicine from July 1, 2017 to June 30, 2020, were selected and dividedinto the observation group and control group according to random number table method, with 40 patients in each group.The patients in the control group were treated with levothyroxine sodium tablets, while the patients in the observationgroup were treated with Taohong Siwu Decoction on the basis of the treatment in the control group. The patients in bothgroups continued to take the drug for 15 d. The clinical efficacy, free triiodothyronine (FT3), free thyroxine (FT4), thy-roid stimulating hormone (TSH), prothrombin time (TT), prothrombin time (PT), activated partial thromboplastin time(APTT), fibrinogen (FIB), platelet count levels fo the two groups before and after operation and adverse reactions werecompared. Results After 15 d of treatment, the total effective rate of treatment in the observation group was 95.0%,which was significantly higher than 85.0% in the control group (P<0.05); the level of FT3 in the observation group was(3.23±0.35) pmol/L versus (2.90±0.44) pmol/L in the control group (P>0.05); the levels of FT4 and TSH in the observa-tion group were (13.53±2.70) pmol/L and (6.02±1.35) μIU/mL versus (11.26±2.68) pmol/L and (7.67±1.42) μIU/mL inthe the control group (P<0.05); the levels of TT, PT, APTT, FIB, and platelet count in the observation group were (20.30±1.56) s, (11.69±0.51) s, (36.75±2.04) s, (7.23±0.36)g/L, (320.71±31.50)×109/L, respectively, which were significantlylower than corresponding (22.74±2.12) s, (13.07±0.43) s, (38.52±2.15) s, (8.80±0.53) g/L, (372.14±29.34)×109/L of thecontrol group (all P<0.05); during the course of treatment, the incidence of adverse reactions in the observation groupwas 5.0% versus 12.5% in the control group (P<0.05). Conclusion After thyroid surgery, Taohong Siwu Decoction caneffectively improve the thyroid function and coagulation function of patients, which is worthy of clinical application.
      【Key words】 Taohong Siwu Decoction; Thyroid surgery; Clinical efficacy; Thyroid function; Coagulation function