标题：膝骨关节炎患者血清 IL-2、IL-6与血管内皮生长因子的相关性

      作者：林军 1，郑秋坚 2，臧学慧 1，贾丙申 3    1.南方医科大学附属南海医院关节科，广东 佛山 528200；2.广东省人民医院关节科，广东 广州 510000；3.海南医学院第一附属医院关节创伤外科，海南 海口 570102

      卷次： 2021年32卷5期

      【摘要】 目的 探讨膝骨关节炎患者血清炎性因子与血管形成相关因子(VEGF)的关系。方法 选择 2015年1月至 2017年 1月南方医科大学附属南海医院关节外科收治的 36例膝骨关节炎患者作为观察组，其中Kellgren-LawrenceⅡ级13例、Ⅲ级14例、Ⅳ级9例，另选择同期体检健康者36例作为对照组，检测并比较两组受试者的血清白细胞介素-2(IL-2)、白细胞介素-6 (IL-6)和VEGF水平，采用 Sperman相关性分析血清 IL-2、IL-6与VEGF的相关性。结果 观察组和对照组受试者的血清 IL-2 [(3.47±0.85) μg/L vs (0.96±0.56) μg/L]、IL-6 [(223.78±26.54) ng/L vs (117.02±14.37) ng/L]、VEGF [(225.16±30.96) ng/L vs (136.71±20.18) ng/L]水平比较，观察组明显高于对照组，差异均有统计学意义(P<0.05)；观察组患者中，Ⅲ级患者的血清 IL-2、IL-6和VEGF水平明显高于Ⅱ级，Ⅳ级患者的血清 IL-2、IL-6和VEGF水平明显高于Ⅲ级，差异均有统计学意义(P<0.05)；Sperman相关性分析结果显示，膝骨关节炎患者血清 IL-2和 IL-6与 VEGF呈显著正相关(r=0.386、0.369，P<0.05)。结论 炎性因子 IL-2、IL-6可能参与了膝骨关节炎的发生和发展，而且与血管内皮因子之间可能存在一定的关系，进而影响新生血管形成。
      【关键词】 膝骨关节炎；炎性因子；血管形成相关因子；相关性
      【中图分类号】 R684.3 【文献标识码】 A 【文章编号】 1003—6350（2021）05—0577—03

Correlation between serum IL-2, IL-6 and vascular endothelial growth factor in patients with kneeosteoarthritis.
LIN Jun 1, ZHENG Qiu-jian 2, ZANG Xue-hui 1, JIA Bin-shen 3. 1. Department of Orthopedics, NanhaiHospital Affiliated to Southern Medical University, Foshan 528200, Guangdong, CHINA; 2. Department of Orthopedics,Guangdong Provincial People's Hospital, Guangzhou 510000, Guangdong, CHINA; 3. Department of Joint Trauma Surgery,First Affiliated Hospital of Hainan Medical College, Haikou 570102, Hainan, CHINA
【Abstract】 Objective To observe and explore the relationship between serum inflammatory factors IL-2, IL-6and vascular endothelial growth factor (VEGF) in patients with knee osteoarthritis. Methods A total of 36 patients withknee osteoarthritis admitted to the Department of Orthopedics, Nanhai Hospital Affiliated to Southern Medical Universi-ty from January 2015 to January 2017 were selected as the observation group. Among them, there were 13 cases of Kell-gren-Lawrence gradeⅡ, 14 cases of gradeⅢ, an d 9 cases of gradeⅣ. In addition, 36 healthy subjects for physical ex-amination during the same period were selected as the control group. Serum levels of interleukin-2(IL-2), interleukin-6(IL-6), and VEGF were detected and compared between the two groups. The correlation between serum IL-2、IL-6 andVEGF was analyzed by Sperman correlation. Results The serum IL-2, IL-6 , VEGF levels were (3.47±0.85) μg/L,(223.78±26.54) ng/L, (225.16±30.96) ng/L in the observation group, which were significantly higher than (0.96±0.56) μg/L,(117.02 ± 14.37) ng/L, (136.71 ± 20.18) ng/L in the control group (P<0.05). In the observation group, the serum IL-2,