标题：Ras-Raf-MAPK/ERK信号通路在正畸牙周组织改建中的表达及调控机制

      作者：袁熳 综述 张疆弢，梅梅 审校    遵义医科大学附属口腔医院正畸科一组，贵州 遵义 563000

      卷次： 2021年32卷4期

      【摘要】 正畸牙周组织改建的基础是牙周膜的存在，牙周膜中最主要的细胞是牙周膜干细胞(periodontalligament stem cells，PDLSCs)，PDLSCs作为机械应力刺激的主要效应细胞，参与牙周组织改建中信号通路的转导，目前已知参与机械应力刺激的信号有Wnt/β-catenin、细胞外信号调节激酶(ERK)、c-Jun N端激酶(JNK)、p38激酶和核因子κB (NF-κB)、Ras、Raf等。它们参与细胞增殖、分化、凋亡的调节，机械转导途径被认为是由共同的信号途径介导的，MAPKs被认为是参与机械传递的最重要的激酶。Ras-Raf-MAPK/ERK通路在PDLSCs成骨分化中起重要作用，更好地理解正畸牙齿运动中的机械反应和所涉及的信号转导途径可能有助于解决正畸治疗中的挑战。因此，本文就Ras-Raf-MAPK/ERK信号通路在正畸牙周组织改建中的表达及调控机制进行综述。
      【关键词】 牙周膜；正畸牙移动；细胞外信号调节激酶；核因子κB；Ras；Raf；MAPK信号通路
      【中图分类号】 R783.5 【文献标识码】 A 【文章编号】 1003—6350（2021）04—0494—05

Expression and regulation mechanism of Ras-Raf-MAPK/ERK signaling pathway in orthodontic periodontaltissue remodeling.
YUAN Man, ZHANG Jiang-tao, MEI Mei. First Group in Department of Orthodontics, AffiliatedStomatological Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, CHINA【Abstract】 The basis of orthodontic periodontal tissue reconstruction is the presence of periodontal ligament.The most important cells in periodontal ligament are periodontal ligament stem cells (PDLSCs). PDLSCs, as the main ef-fector cells of mechanical stress stimulation, participate in the transduction of signal pathways in periodontal tissue re-construction. Currently known signals involved in mechanical stress stimulation are Wnt/β-catenin, extracellular sig-nal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 kinase, nuclear factor-κB (NF-κB), Ras, Raf. They areinvolved in the regulation of cell proliferation, differentiation, and apoptosis. The mechanical transduction pathways be-lieved to be mediated by a common signal pathway, and MAPKs are the most important kinases involved in mechanicaltransmission. The Ras-Raf-MAPK/ERK pathway plays an important role in the osteogenic differentiation of PDLSCs,and to better understand the mechanical response and the signal transduction pathway involved in orthodontic toothmovement may help solve challenges in orthodontic treatment. Therefore, this article reviews the research progress ofRas-Raf-MAPK/ERK signaling pathway involved in periodontal tissue remodeling.
      【Key words】 Periodontal ligament; Orthodontic tooth movement; Extracellular signal regulated kinase; Nuclearfactor-κB (NF-κB); Ras; Raf; MAPK signaling pathway·综述·doi:10.3969/j.issn.1003-6350.2021.04.024基金项目：贵州省遵义市科技局/遵义医科大学附属口腔医院联合资助项目(编号：遵市科合社字[2018]245)