标题：早期上呼吸道NK/T细胞淋巴瘤治疗进展

      作者：潘粤勇 1，陈兴贵 2 综述 吴华 2审校    1.广东医科大学第一临床医学院，广东 湛江 524000；2.广东医科大学附属医院肿瘤中心，广东 湛江 524000

      卷次： 2021年32卷3期

      【摘要】 结外NK/T细胞淋巴瘤(ENKL)是EB病毒(EBV)相关的常见非霍奇金淋巴瘤(NHL)，多见于NK细胞，偶见T细胞系。主要累及鼻腔、鼻咽、咽喉等上呼吸道，临床表现为发热、鼻塞、鼻出血，常伴有恶臭。初步评估主要包括血浆EBV-DNA定量、头颈部增强MRI、PET/CT等，确诊需行肿瘤病理学检查。早期低危患者单纯放疗有较高的生存，中高危者单纯放疗远处转移发生率较高。早期低危患者可行单纯放射治疗，早期中高危患者治疗模式争议较大，目前建议放化疗相结合的综合治疗，L-天门冬酰胺酶(或培门冬酶)为基础方案是目前常用的化疗方案。对于早期中高危患者，最佳的治疗模式仍有待进一步研究。
      【关键词】 早期；上呼吸道；NK/T细胞淋巴瘤；治疗；进展
      【中图分类号】 R733.4 【文献标识码】 A 【文章编号】 1003—6350（2021）03—0364—05

Progress in the treatment of early-stage upper respiratory tract NK/T cell lymphoma.
PAN Yue-yong 1, CHENXing-gui 2, WU Hua 2. 1. The First Clinical Medical College of Guangdong Medical University, Zhanjiang 524000,Guangdong, CHINA; 2. Cancer Center, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000,Guangdong, CHINA【Abstract】 Extranodal natural killer/T-cell lymphoma (ENKL) is a common non-Hodgkin's lymphoma (NHL) re-lated to EB virus (EBV), which occurs mostly in NK cells and occasionally in T cell lines. It mainly involves the nasalcavity, nasopharynx, throat and other upper respiratory tract, and the main clinical manifestations are fever, nasal conges-tion, nosebleed, often accompanied by foul odor. The preliminary evaluation mainly included plasma EBV-DNA quantifi-cation, head and neck enhanced MRI, PET/CT, etc. Pathological examination of the tumor is required for diagnosis. Thesurvival rate of early low-risk patients is higher and the incidence of distant metastasis is higher in middle and high-riskpatients. Radiotherapy alone is feasible for low-risk patients in the early stage, while the treatment mode for high-risk pa-tients in the early stage is controversial. Currently, comprehensive treatment combining radiotherapy and chemotherapyis recommended, and L-asparaginase (or PMT) -based regimen is the commonly used chemotherapy regimen at present.The optimal treatment modality for early-stage high-risk patients is still under investigation.
      【Key words】 Early-stage; Upper respiratory tract; NK/T cell lymphoma; Treatment; Progress·综述·doi:10.3969/j.issn.1003-6350.2021.03.025