标题：Semaphorin家族调控APC与T细胞相互作用的研究进展

      作者：宋香芋 1，2 综述 文瑞婷 2，杨志刚 2 审校    1.广东医科大学，广东 湛江 524000；2.广东医科大学附属湛江中心医院血液内科，广东 湛江 524000

      卷次： 2021年32卷3期

      【摘要】 信号素(Semaphorin)家族最初被认为是在神经轴突发育过程中起着导向作用的信号分子。最近，越来越多的研究表明Semaphorin家族在免疫系统中也具有重要作用。Semaphorin家族中的不同分子可以结合相应的受体，参与生理或病理性免疫反应的不同阶段，包括免疫细胞的活化、分化、增殖及迁移。本文就国内外关于Sema-phorin家族调控抗原呈递细胞和T细胞相互作用的研究进展做一综述，为进一步探究其在疾病中的作用提供参考。
      【关键词】 信号素；免疫反应；抗原呈递细胞；T细胞；相互作用
      【中图分类号】 R329.2 【文献标识码】 A 【文章编号】 1003—6350（2021）03—0346—04

Research progress on semaphorin family for regulating the interaction between antigen-presenting cells and Tcells.
SONG Xiang-yu 1, 2, WEN Rui-ting 2, YANG Zhi-gang 2. 1. Guangdong Medical University, Zhanjiang 524000,Guangdong, CHINA; 2. Department of Hematology, Zhanjiang Central Hospital Affiliated to Guangdong Medical University,Zhanjiang 524000, Guangdong, CHINA【Abstract】 Semaphorin family was originally thought to be signaling molecules that play a guiding role in thedevelopment of axons. Recently, more and more studies have shown that semaphorin family also plays an important rolein the immune system. Different molecules in semaphorin family can bind to corresponding receptors and participate indifferent stages of physiological or pathological immune responses, including the activation, differentiation, prolifera-tion, and migration of immune cells. In this review, recent advances in research of semaphorin in regulating the interac-tion between antigen-presenting cells (APC) and T cells are summarized and discussed to provide reference for furtherexploring its role in diseases.
      【Key words】 Semaphorin; Immune response; Antigen-presenting cell; T cell; Interaction·综述·doi:10.3969/j.issn.1003-6350.2021.03.021基金项目：广东省普通高校省级重大科研项目(编号：2017KZDXM042)