标题：高血压患者视网膜病变与血清脂蛋白相关磷脂酶A2的相关性

      作者：吴玉呈 1，张青青 2    泰州市人民医院心内科 1、内分泌科 2，江苏 泰州 225300

      卷次： 2021年32卷3期

      【摘要】 目的 检测高血压患者血清脂蛋白相关磷脂酶A2 (Lp-PLA2)水平，并探讨其与视网膜病变的相关性。方法 选取2019年1月至2020年8月在南通大学附属泰州市人民医院心内科住院的116例高血压患者为研究对象，根据是否合并视网膜病变分为单纯高血压64例(对照组)和高血压视网膜病变(HRP) 52例(观察组)。检测并比较两组患者的血清Lp-PLA2、血糖、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白AI (ApoAI)、载脂蛋白B (ApoB)指标。采用Spearson相关性分析及二元Logistic回归分析探讨Lp-PLA2与视网膜病变的相关性。结果 观察组患者的女性比例、高血压病程、糖尿病患病率、Lp-PLA2水平分别为53.85%、(9.58±1.32)年、57.69%、(152.35±39.48) ng/mL，明显高于对照组的34.38%、(7.34±1.12)年、37.5%、(112.18±28.86 ) ng/mL，差异均具有统计学意义(P<0.05)；经 Spearson相关分析结果显示，Lp-PLA2与TG、脂蛋白(a)、ApoAI/ApoB、HRP呈正相关性 (r=0.077、0.139、0.051、0.165，P<0.05)，与 HDL-C呈显著负相关 (r=-0.084，P<0.05)；二元Logistic回归分析结果显示，在校正性别、高血压病程、糖尿病病史后，Lp-PLA2仍是HRP的独立危险因素(P<0.05)。结论 Lp-PLA2与HRP具有相关性，是HRP的独立危险因素，提示早期检测Lp-PLA2水平对预测高血压患者视网膜病变的发生具有一定的临床价值。
      【关键词】 脂蛋白相关磷脂酶A2；高血压；视网膜病变；血脂；相关性分析；Logistic回归分析
      【中图分类号】 R544.1 【文献标识码】 A 【文章编号】 1003—6350（2021）03—0293—04

Relationship between lipoprotein associated phospholipase A2 and retinopathy in patients with hypertension.
WUYu-cheng 1, ZHANG Qing-qing 2. Department of Cardiology 1, Department of Endocrinology 2, Taizhou People's Hospital,Taizhou 225300, Jiangsu, CHINA
【Abstract】 Objective To investigate the lipoprotein associated phospholipase A2 (Lp-PLA2) level in hyperten-sive patients and to explore the relationship between Lp-PLA2 and retinopathy in hypertensive patients. Methods Thesubjects were selected from the Department of Cardiology, Taizhou People's Hospital Affiliated to Nantong Universi-ty from January 2019 to August 2020, who were divided into hypertension without retinopathy group (control group,64 cases) and hypertension with retinopathy group (observation group, 52 cases). Serum Lp-PLA2, blood glucose, tri-glyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholester-ol (LDL-C), ApoAI, ApoB were detected and compared between the two groups. Spearson correlation analysis and bi-nary logistic regression analysis were used to explore the correlation between Lp-PLA2 and retinopathy. Results The