标题：东莞地区新型冠状病毒肺炎的临床特点

      作者：卢伟波，周柳如，陈卫民，徐汝洪，黎玉燕，张平    东莞市人民医院呼吸与危重症医学科，广东 东莞 523000

      卷次： 2021年32卷1期

      【摘要】 目的 分析东莞地区新型冠状病毒肺炎(COVID-19)的临床特点。方法 回顾性分析东莞市第九人民医院呼吸与危重症医学科于2020年 1月21日至3月7日收治的100例COVID-19患者的临床资料。结果 100例患者年龄2~79岁，平均(37.13±18.01)岁；男性52例，女性48例；潜伏期1~24 d，平均(11.14±6.05) d；就诊时主要症状有发热(62%)、咳嗽(54 %)、乏力(39%)、气促(8%)、头痛(30%)、肌肉酸痛(21%)，无症状(13%)；80%患者白细胞计数正常，18%白细胞计数偏低；42%淋巴细胞计数偏低，57%淋巴细胞计数正常；胸部CT提示单肺叶病变22.22%，单肺病变3.03%，62.63%出现双肺多肺叶病变，12.12%肺部未见明显病变；病变多表现为小斑片影及间质改变，以肺外带为主，间有磨玻璃影、浸润影改变。入院时轻型 28例，普通型 70例，重型 2例，其中 12例转变为危重型，1例死亡。经验性治疗为洛匹那韦/利托那韦、阿比多尔、α-干扰素、磷酸氯喹抗病毒、中医调理及支持治疗并必要时用抗生素。结论 COVID-19具有传染性，发热、咳嗽、乏力、外周血白细胞、淋巴细胞正常或降低及胸部CT示肺外周磨玻璃阴影是该病的临床特点。
      【关键词】 新型冠状病毒；新型冠状病毒肺炎；传染性；临床特点；回顾性分析
      【中图分类号】 R511 【文献标识码】 A 【文章编号】 1003—6350（2021）01—0085—03

Clinical characteristics of coronavirus disease 2019 in Dongguan: a retrospective study.
LU Wei-bo, ZHOU Liu-ru,CHEN Wei-min, XU Ru-hong, LI Yu-yan, ZHANG Ping. Department of Pulmonary and Critical Care Medicine, DongguanPeople's Hospital, Dongguan 523000, Guangdong, CHINA
【Abstract】 Objective To explore the characteristics of the coronavirus disease 2019 (COVID-19) in Dong-guan City. Methods The clinical data regarding 100 patients with confirmed COVID-19 in Ninth People's Hospital ofDongguan from January 21 to March 7, 2020 were collected and analyzed. Results The patients ranged from 2 to 79years old, with a mean age of (37.13±18.01) years, including 52 males and 48 females. The incubation period rangedfrom 1 to 24 days, with a mean period of (11.14±6.05) days. The most common symptoms included fever (62%), cough(54%), fatigue (39%), shortness of breath (8%), headache (30%), muscle soreness (21%), without symptoms (13%); 80%of the patients had normal leukocytes and 18% had leucopenia; 42% had lymphopenia and 57% had normal lymphocyte.Chest computed tomography (CT) showed single lobe lesions in 22.22% patients, multi lobes lesions in one lung in3.03% patients, multi lobes lesions in two lungs in 62.63% patients, and no obvious lung lesion in 12.12% patients. Mostof the lesions were small spot shadows and interstitial changes in the outer zone of the lung, and sometimes wereground-glass opacities or infiltration shadows. At admission, there were 28 patients of light type, 70 patients of ordinarytype, and 2 patients of severe type, of which 12 patients turned into critical type and 1 died. Most common treatment in-cluded lopinavir/ritonavir, abidol, α-interferon, chloroquinephosphate, traditional Chinese medicine, support treatmentand antibiotics if necessary. Conclusion COVID-19 is infectious, and the clinical characteristics included fever,cough, fatigue, normal or decreased leukocytes and lymphocytes and ground-glass opacities at the outer zone of lung inchest CT.
      【Key words】 Novel coronavirus; Coronavirus disease 2019; Infectious; Clinical characteristics; Retrospectivestudy·短篇论著·doi:10.3969/j.issn.1003-6350.2021.01.023基金项目：广东省东莞市科技局项目(编号：202071715001120)