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      标题:纳布啡联合舒芬太尼对开腹肝切除术患者术后镇痛及生活质量的影响
      作者:牟俊英 1,朱贤林 1,叶刚 1,刘涛 2    恩施土家族苗族自治州中心医院麻醉科 1、肝胆胰脾外科 2,湖北 恩施 445000
      卷次: 2021年32卷1期
      【摘要】 目的 探讨纳布啡联合舒芬太尼对开腹肝切除术患者术后镇痛及生活质量的影响。方法 选择2019年1月至2020年1月在恩施土家族苗族自治州中心医院拟行开腹肝切除术患者80例,按随机数表法分为舒芬太尼组(S组)和纳布啡联合舒芬太尼组(NS组),每组40例。记录并比较两组患者术后2 h、6 h、12 h、24 h、48 h的术前视觉模拟(VAS)评分和Ramsay镇静评分及不良反应发生率;并比较两组患者术后补救镇痛例数、术后首次下床时间及肛门通气时间,术前1 d、术后24 h和术后48 h的QoR-15量表评分。结果 与S组比较,NS组患者术后24 h和 48 h的VAS评分分别为 3 (3,4)分、3 (2,3)分,明显低于 S组的 4 (3,4)分、4 (3,4)分,差异均有统计学意义(P<0.05);NS组患者术后6 h、12 h、24 h及48 h的Ramsay镇静评分明显低于S组,差异均有统计学意义(P<0.05);与S组比较,NS组患者的头晕、恶心呕吐等术后不良反应发生率更低,术后首次下床时间及肛门通气时间更早,差异均有统计学意义(P<0.05);NS组术后 24 h的QoR-15量表评分及 48 h的QoR-15量表评分分别为(98.13±17.60)分、(106.38±13.35)分,明显高于S组的(88.50±15.28)分和(100.88±10.68)分,差异均有统计学意义(P<0.05)。结论 纳布啡联合舒芬太尼对开腹肝切除术患者的术后镇痛效果好,不良反应发生率低,术后生活质量更高。
      【关键词】 纳布啡;舒芬太尼;联合用药;肝切除术;术后镇痛;生活质量
      【中图分类号】 R657.3 【文献标识码】 A 【文章编号】 1003—6350(2021)01—0038—04

Effect of nalbuphine combined with sufentanil on postoperative analgesia and quality of life in patientsundergoing open hepatectomy.

MOU Jun-ying 1, ZHU Xian-lin 1, YE Gang 1, LIU Tao 2. Department of Anesthesiology 1,Department of Hepatobiliary Surgery 2, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000,Hubei, CHINA
【Abstract】 Objective To investigate the effect of nalbuphine combined with sufentanil on postoperative anal-gesia and quality of life in patients undergoing open hepatectomy. Methods From January 2019 to January 2020, 80 pa-tients underwent open hepatectomy under subcostal transversus abdominis plane block combined with general anesthesiain the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, were randomly and equally divided into sufent-anil group (group S) and nabulphine combined with sufentani group (group NS) by using random number table method,with 40 patients in each group. The Visual Analogue Scale (VAS) and Ramsay sedation scores of 2 hours, 6 hours, 12hours, 24 hours and 48 hours after surgery in the two groups, as well as side effects such as dizziness, nausea, vomiting,

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