标题:加味八珍汤联合化疗对子宫内膜癌患者T细胞亚群水平、止痛效果及生存质量的影响
作者:徐珊,裴巧丽,杜东青,宋丽华 陕西中医药大学第二附属医院产科,陕西 咸阳 712000
卷次:
2021年32卷1期
【摘要】 目的 探究加味八珍汤联合化疗对子宫内膜癌患者T细胞亚群水平、止痛效果及生存质量的影响。方法 选取2013年5月至2017年10月于陕西中医药大学第二附属医院收治的104例子宫内膜癌患者为研究对象,按随机数表法分为观察组和对照组,每组 52例,对照组患者行常规化疗治疗,观察组患者在对照组治疗的基础上给予加味八珍汤治疗。7 d为一个疗程,两组均治疗 3个疗程。比较两组患者治疗前后的中医症状积分、T细胞亚群水平、视觉模拟评分法(VAS)、癌症患者生命质量测定量表(FACT-G)评分和卡式功能状态评分(KPS),并在治疗后 3个月评价两组患者的疗效和不良反应发生情况。结果 治疗前两组患者的中医症状积分、T细胞亚群水平、疼痛评分、生存质量评分比较,差异均无统计学意义(P>0.05);治疗后,观察组和对照组患者的中医症状积分[(12.66±2.52)分vs (16.38±2.98)分]、CD8+ [(23.94±3.92)% vs (27.86±4.31)%]、VAS评分[(5.04±1.72)分vs (6.37±1.96)分]比较,观察组明显低于对照组;CD3+ [(62.81±8.13)% vs (57.14±7.69)%]、CD4+ [(42.63±6.28)% vs (36.61±5.25)%]、自然杀伤细胞(NK)细胞水平[(41.59±6.13)% vs (36.75±5.12)%]比较,观察组明显高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者的FACT-G评分和KPS评分分别为(58.96±7.22)分、(61.27±8.43)分,明显高于对照组的(45.73±6.49)分、(49.82±6.64)分,差异均有统计学意义(P<0.05);观察组患者近期治疗总有效率为86.54%,明显高于对照组的67.31%,不良反应率为15.38%,明显低于对照组的32.69%,差异均有统计学意义(P<0.05)。结论 加味八珍汤应用于子宫内膜癌化疗患者可显著改善症状,减轻疼痛度,增强细胞免疫水平,提高治疗效果,改善生存质量,并可降低不良反应率。
【关键词】 子宫内膜癌;加味八珍汤;化疗;T细胞亚群;生存质量
【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350(2021)01—0022—04
Effect of Jiawei bazhen decoction combined with chemotherapy on T-cell subgroup, analgesic effect, and qualityof life in patients with endometrial carcinoma.
XU Shan, PEI Qiao-li, DU Dong-qing, SONG Li-hua. Department ofObstetrics, the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, Shaanxi,CHINA
【Abstract】 Objective To investigate the effect of Jiawei Bazhen Decoction combined with chemotherapy on Tcell subsets, analgesia, and quality of life in patients with endometrial carcinoma. Methods A total of 104 patients withendometrial cancer, who treated in the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicinefrom May 2013 to October 2017, were selected and divided into the control group and observation group according torandom number table method, with 52 patients in each group. The control group was treated with conventional chemo-therapy, and the observation group was given Jiawei Bazhen Decoction on the basis of the control group. A course oftreatment included 7 days, and the two groups were treated for three courses. Traditional Chinese Medicine (TCM) symp-tom score, T cell subsets level, visual analogue scale (VAS), and functional assessment of cancer therapy-general(FACT-G) of the two groups were observed before and after treatment, and the short-term (3 months after treatment) effi-cacy and adverse reactions were evaluated. Results There was no significant difference in symptom scores, T cell sub-sets, VAS, and FACT-G between the two groups before treatment (all P>0.05). After treatment, TCM symptom score,CD8+, VAS score in the observation group were (12.66±2.52) points, (23.94±3.92)%, (5.04±1.72) points, respectively,which were significantly lower than corresponding (16.38±2.98) points, (27.86±4.31)%, (6.37±1.96) points in the controlgroup, while CD3+, CD4+, and natural killer cell (NK) levels were (62.81±8.13)%, (42.63±6.28)%, (41.59±6.13)%, respec-tively, which were significantly higher than corresponding (57.14±7.69)%, (36.61±5.25)%, (36.75±5.12)% in the controlgroup (all P<0.05). The scores of FACT-G and Karnofsky performance status (KPS) in the observation group were (58.96±7.22) points and (61.27±8.43) points, which were significantly higher than corresponding (45.73±6.49) points and (49.82±6.64) points in the control group (P<0.05); the total effective rate of treatment in the observation group was 86.54% ver-
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