标题：高胆红素血症新生儿血清NPY、S100B蛋白、B/A比值与胆红素脑损伤的关系

      作者：代红 1，范小康 2    咸阳市中心医院新生儿科 1、儿科 2，陕西 咸阳 712000

      卷次： 2020年31卷23期

      【摘要】 目的 研究高胆红素血症新生儿血清神经肽Y (NPY)、S100B蛋白、总胆红素/白蛋白(B/A)比值与胆红素脑损伤的关系。方法 将咸阳市中心医院2016年1月至2018年12月期间收治的120例高胆红素血症新生儿纳入研究。将其按照脑损伤程度分为轻度组53例和中重度组67例，另取60例健康新生儿作为对照组。检测并比较三组新生儿的血清总胆红素(TSB)、NPY、S100B蛋白、B/A比值，对比三组新生儿行为神经测定量表(NBNA)评分。采用Pearson相关性分析法分析高胆红素血症新生儿血清NPY、S100B蛋白、B/A比值与TSB、NBNA评分的相关性。结果 三组新生儿的性别、日龄、胎龄、出生体质量比较差异均无统计学意义(P>0.05)；轻度组与中重度组新生儿的TSB、NPY、S100B、B/A比值明显高于对照组，且中重度组新生儿上述各项指标水平明显高于轻度组，差异均有统计学意义(P<0.05)；轻度组与中重度组新生儿的各项NBNA评分明显低于对照组，且中重度组新生儿的各项NBNA评分明显低于轻度组，差异均有统计学意义(P<0.05)；经Pearson相关性分析结果显示，高胆红素血症新生儿血清NPY、S100B蛋白、B/A比值均与 TSB呈正相关(r=0.523、0.582、0.601，P<0.05)，均与NBNA评分呈负相关(r=-0.566、-0.594、-0.632，P<0.05)。结论 高胆红素血症新生儿血清NPY、S100B蛋白、B/A比值与胆红素脑损伤密切相关，有可能成为早期预测高胆红素血症新生儿胆红素脑损伤的有效指标。
      【关键词】 高胆红素血症；脑损伤；神经肽Y；血清总胆红素/白蛋白；S100B蛋白
      【中图分类号】 R722.1 【文献标识码】 A 【文章编号】 1003—6350（2020）23—3050—04

Relationship between serum NPY, S100B protein, B/A ratio, and bilirubin brain injury in neonates withhyperbilirubinemia.
DAI Hong 1, FAN Xiao-kang 2. Department of Neonatology 1, Department of Pediatrics 2, XianyangCentral Hospital, Xianyang 712000, Shaanxi, CHINA
【Abstract】 Objective To study the relationship between serum neuropeptide Y (NPY), S100B protein, total bil-irubin/albumin (B/A) ratio, and bilirubin brain injury in neonates with hyperbilirubinemia. Methods A total of 120 neo-nates with hyperbilirubinemia who were admitted to Xianyang Central Hospital from January 2016 to December 2018were included in the study. According to the degree of brain injury, they were divided into the mild group with 53 casesand the moderate and severe group with 67 cases. Another 60 healthy newborns were selected as the control group. Se-rum total bilirubin (TSB), NPY, S100B protein, and B/A ratio of neonates in the three groups were detected and com-pared, and NBNA scores among three groups were compared. Pearson correlation analysis was used to analyze the corre-lation between serum NPY, S100B protein, B/A ratio and TSB, Neonatal Behavioral Neurological Assessment (NBNA)scores in neonates with hyperbilirubinemia. Results The gender, day age, gestational age and birth mass of the neo-nates among the three groups showed no statistically significant difference (P>0.05). The TSB, NPY, S100B, and B/A ra-tio in the mild group and the moderate and severe group were all significantly higher than those in the control group, and