标题：多西他赛每周方案联合放疗治疗老年局部晚期食管癌的临床疗效观察

      作者：熊慧如，尤传文，陆锡燕，陈建章
    (南京市鼓楼医院集团宿迁市人民医院肿瘤科，江苏 宿迁 223800)

      卷次： 2013年24卷6期

      【摘要】 目的 探讨多西他赛每周方案化疗联合放疗治疗老年局部晚期食管癌的临床疗效。方法 我科
收治的70例老年局部晚期食管癌患者，随机分为放化组(多西他赛每周方案联合放疗，n=36)和单放组(单纯放射
治疗，n=34)，两组放疗均采用三维适形放疗(3DCRT)，照射剂量60~66 Gy。放化组采用多西他赛40 mg/次，于放
疗的第 1、8、15、22、29、36天使用，连续 6周。结果 70例患者均可评价疗效，放化组及单放组有效率(RR=CR+
PR)分别为88.9% ,67.6%；放化组1、2、3年生存率为69.4%、58.3%和47.2%；单放组为44.1%、32.4%和23.5%。两
组比较差异有统计学意义(P<0.05)。放化疗组骨髓抑制、胃肠道反应、放射性食管炎等毒副反应稍高于单放疗
组(P>0.05)。结论 多西他赛每周方案联合放疗治疗老年局部晚期食管癌疗效显著，毒副反应可耐受。

      【关键词】 老年食管癌；多西他赛；放化疗；疗效

      【中图分类号】 R735.1 【文献标识码】 A 【文章编号】 1003—6350（2013）06—0793—03


Effect of weekly dose of docetaxel combined with radiotherapy in the treatment of elderly patients with
esophageal cancer.
XIONG Hui-ru, YOU Chuan-wen, LU Xi-yan, CHEN Jian-zhang. Department of Oncology, Suqian
People's Hospital, Nanjing Drum Tower Hospital Group, Suqian 223800, Jiangsu, CHINA

【Abstract】 Objective To investigate the efficacy and toxicity of weekly dose of docetaxel combined with ra-
diotherapy in the treatment of elderly patients with esophageal cancer. Methods Seventy elderly patients with esoph-
ageal cancer treated in our department were randomly divided into chemoradiotherapy group (docetaxel combined
with radiotherapy, n=36) and radiotherapy group (radiotherapy only, n=34). Patients in both groups received conven-
tional radiotherapy (3DCRT) with a total dose of 60~66 Gy. In chemoradiotherapy group, 40 mg docetaxel was admin-
istered once a week on the 1st, 8th, 15th, 22th, 29th, 36th for six successive weeks. Results The efficacy of all the patients
was evaluated. The response rate (CR + RR) was 88.9% and 67.6% for chemoradiotherapy group and radiotherapy
group, respectively. The 1-, 2- and 3-year survival rate was 69.4% , 58.3% , 47.2% in chemoradiotherapy group,
44.1% , 32.4% , 23.5% in radiotherapy group, respectively, with statistically significant difference between the two
groups (P<0.05). The incidence of myelosuppression, gastrointestinal tract, and esophagitis were slightly higher in
chemoradiotherapy group than radiotherapy group (P>0.05). Conclusion Weekly dose of docetaxel combined with
radiotherapy can effectively treat esophageal cancer in elderly patients, and the toxic reactions were tolerable.