标题：神经生长因子在胃腺癌组织中的表达及其与神经受浸的相关性研究

      作者：胡海霞，李 伟，熊正文，李宏伟，黄 勇，苏 红
    （中国人民解放军第251医院病理科，河北 张家口 075000）

      卷次： 2013年24卷6期

      【摘要】 目的 探讨神经生长因子在胃腺癌组织中的表达及神经受浸的情况，并分析其与临床病理因
素的关系。方法 采用免疫组织化学(EnVisionTM)法检测神经生长因子（NGF）在胃腺组织及癌旁组织中的表
达。结果 NGF在癌旁组织中的阳性表达率为 6.66%，其在胃腺组织中的阳性表达率为 51.25%，差异有统计
学意义(P<0.01)；NGF的阳性表达率与患者年龄、肿瘤直径、组织学分级及浸润深度无关，差异无统计学意义
(P>0.05)，但与淋巴结转移及神经受浸有关，差异有统计学意义（P<0.01）。结论 NGF在胃腺组织中过表达，预
示着患者预后不良及神经易受浸。

      【关键词】 神经生长因子；胃腺癌；神经受浸；免疫组织化学

      【中图分类号】 R735.2 【文献标识码】 A 【文章编号】 1003—6350（2013）06—0788—02


Expression of nerve growth factor in gastric adenocarcinoma and its correlation with nerve invasion.
HU
Hai-xia, LI Wei, XIONG Zheng-wen, LI Hong-wei, HUANG Yong, SU Hong. Department of Pathology, the 251st Hospital
of Chinese PLA, Zhangjiakou 075000, Hebei, CHINA

【Abstract】 Objective To investigate the expression of nerve growth factor (NGF) in gastric carcinoma and
the situation of nerve invasion, and analyze the relationship between nerve growth factor and clinicopathological fac-
tors. Methods NGF was detected in gastric carcinoma and paracancerous tissue by immunohistochemistry (EnVi-
sionTM). Results The positive expression rate of NGF was 6.66% in paracancerous tissue and 51.25% in gastric car-
cinoma, showing statistically significant difference (P<0.01). The positive expression rate of NGF was not related to
age, tumor size, histological classification, infiltrated depth, with no statistically significant difference among them
(P>0.05). The positive expression rate of NGF was related to lymphatic nodes metastasis and nerve invasion, with sta-
tistically significant difference (P<0.01). Conclusion The over-expression of NGF in gastric carcinoma indicates un-
favorable prognosis and nerve invasion.

      【Key words】 Nerve growth factor; Gastric adenocarcinoma; Nerve invasion; Immunohistochemistry