标题：宫颈癌筛查方法及其进展

      作者：郑楚丽，宋硕，谭晓瑜 综述 符爱珍 审校    广东医科大学，广东 湛江 524000

      卷次： 2021年32卷5期

      【摘要】 子宫颈癌起源于子宫颈上皮内瘤变，筛查发现子宫颈上皮内瘤变并积极治疗是预防子宫颈癌的有效措施。目前常用的宫颈癌筛查方法包括细胞学检查及人乳头瘤病毒(HPV)检测。细胞学检查及HPV检测均有新的筛查方法及进展。细胞学检查除了传统的巴氏细胞学检测及目前常用的液基细胞学检测，现部分医院开始采用细胞DNA倍性分析、P16/Ki67双染等方法辅助诊断。而HPV检测除了常规的HPV DNA检测，现较热门的是HPVE6/E7 mRNA检测，HPV E6/E7 mRNA检测可补充细胞学检查及HPV DNA检测的不足。现综述目前所采用的宫颈癌筛查方法及进展，为临床上宫颈癌筛查方法选择提供参考。
      【关键词】 子宫颈；宫颈上皮内瘤变；乳头状瘤病毒科；巴氏细胞学检查；液基细胞学检查；HPV E6/E7mRNA；宫颈癌筛查
      【中图分类号】 R737.33 【文献标识码】 A 【文章编号】 1003—6350（2021）05—0662—04

Methods and progress of cervical cancer screening.
ZHENG Chu-li, SONG Shuo, TAN Xiao-yu, FU Ai-zhen.Guangdong Medical University, Zhanjiang 524000, Guangdong, CHINA【Abstract】 Cervical cancer originated from cervical intraepithelial neoplasia, and screening and active treatmentare effective measures to prevent cervical cancer. The most commonly used methods for cervical cancer screening in-clude cytology and human papillomavirus testing. There are new screening methods and progress in cytology and HPVtesting. In addition to the traditional Papanicolaou cytology test and the commonly used liquid-based cytology test, DNAploidy analysis and P16/Ki67 double staining have been used to assist the diagnosis in some hospitals. In addition to con-ventional HPV DNA testing, HPV E6/E7 mRNA testing is now more popular, which can supplement cytology and HPVDNA detection deficiencies. This article reviews the current methods and progress of cervical cancer screening for clini-cal cervical cancer screening methods to provide reference.
      【Key words】 Cervix uteri; Cervical intraepithelial neoplasia; Papillomaviridae; Pap cytology; Liquid-based cytol-ogy; HPV E6/E7 mRNA; Cervical cancer screening·综述·doi:10.3969/j.issn.1003-6350.2021.05.034