标题：脓毒症中CD4+T淋巴细胞凋亡的研究进展

      作者：黄丽 1 综述 曹殿青 2 审校    1.广东医科大学，广东 湛江 524000；2.广东医科大学附属医院麻醉科，广东 湛江 524000

      卷次： 2021年32卷5期

      【摘要】 脓毒症是指由威胁生命的严重感染而引起全身炎症反应综合征和免疫功能障碍的多器官功能障碍综合征。T淋巴细胞是获得性免疫细胞亚群之一，而脓毒症免疫细胞中CD4+T淋巴细胞的凋亡占重要的地位，因其与脓毒症的发生及随后的免疫抑制息息相关。多项研究表明，预防CD4+T淋巴细胞的凋亡可以提高脓毒症的存活率。进一步探究脓毒症中CD4+T细胞发生凋亡的机制并采取有效措施减少这一现象的发生，是目前脓毒症治疗研究的重点和急需突破的方向之一。
      【关键词】 脓毒症；CD4+T淋巴细胞；凋亡；糖酵解；免疫；葡萄糖转运蛋白酶1；信号通路
      【中图分类号】 R631 【文献标识码】 A 【文章编号】 1003—6350（2021）05—0651—03

Research advance on apoptosis of CD4 + T lymphocytes in sepsis.
HUANG Li 1, CAO Dian-qing 1，2. 1. GuangdongMedical University, Zhanjiang 524000, Guangdong, CHINA; 2. Department of Anesthesiology, the Affiliated Hospital ofGuangdong Medical University, Zhanjiang 524000, Guangdong, CHINA【Abstract】 Sepsis refers to multiple organ dysfunction syndrome in which systemic inflammatory response syn-drome and immune dysfunction are caused by serious life-threatening infections. T lymphocytes are one of the sub-groups of acquired immune cells, and the apoptosis of CD4+ T lymphocytes in sepsis immune cells occupies an impor-tant position, because it is closely related to the occurrence of sepsis and subsequent immunosuppression. A number ofstudies have shown that preventing the apoptosis of CD4+ T lymphocytes can improve the survival rate of sepsis. Further,to explore the mechanism of CD4+ T cell apoptosis in sepsis and take effective measures to reduce the occurrence of thisphenomenon is one of the current focus of sepsis treatment research and one of the directions that urgently need to bebroken.
      【Key words】 Sepsis; CD4 + T lymphocytes; Apoptosis; Glycolysis; Immunity; Glucose transporter 1; Signalingpathway·综述·doi:10.3969/j.issn.1003-6350.2021.05.031