标题：TGF-β1/Smad信号通路与糖尿病肾病关系的研究进展

      作者：赵婷 综述 张祥贵 审校    遵义医科大学第五附属(珠海)医院肾内科，广东 珠海 519000

      卷次： 2021年32卷5期

      【摘要】 糖尿病肾病(DKD)是糖尿病的常见并发症，为终末期肾脏病的主要病因之一。DKD中糖代谢障碍所致炎症、氧化应激及糖基化终末产物等改变不同程度促使转化生长因子-β1 (TGF-β1)表达增加，加速病情进展。其中，TGF-β1与其受体结合并激活下游信号蛋白发挥生物学作用。Smads蛋白作为下游信号蛋白与TGF-β1组成了经典信号传导通路，参与了肾纤维化的病理过程。为进一步延缓肾纤维化进程，提升DKD治疗效果，必须全面了解TGF-β1/Smad信号通路在DKD的发病机理中涉及的分子机制。因此，本文概述了TGF-β1/Smad信号通路在DKD发病中的最新发现。
      【关键词】 糖尿病肾病；转化生长因子-β1；Smads；信号通路；肾纤维化；糖基化终末产物；氧化应激
      【中图分类号】 R587.2 【文献标识码】 A 【文章编号】 1003—6350（2021）05—0642—05

Research progress of relationship between TGF-β 1/Smad signaling pathway and diabetic nephropathy.
ZHAOTing, ZHANG Xiang-gui. Department of Nephrology, the Fifth Afiliated (Zhuhai) Hospital of Zunyi Medical University,Zhuhai 519000, Guangdong, CHINA【Abstract】 Diabetic kidney disease (DKD) is a common complication of diabetes and one of the main causes ofend-stage kidney disease. The changes of hyperglycemia, oxidative stress and inflammation caused by carbohydrate me-tabolism disorders in DKD increase the expression levels of transforming growth factors (TGF) in varying degrees andaccelerate the progression of the disease. Among them, TGFs play a biological role by binding to its receptors and acti-vating downstream signaling proteins. The Smads protein, as a downstream signaling protein, constitutes a classical sig-naling pathway with TGF-β1, and participates in the pathological process of renal fibrosis. For purpose of further delay-ing the process of renal fibrosis and improving the therapeutic effect of DKD, it is necessary to fully understand the mo-lecular mechanism involved in the pathogenesis of the TGF-β 1/Smad signaling pathway in DKD. Therefore, this papersummarizes the latest findings of the TGF-β1/Smad signaling pathway in DKD pathogenesis.
      【Key words】 Diabetic kidney disease (DKD); Transforming growth factor β1 (TGF-β1); Smads; Signal transduc-tion; Renal fibrosis; Advanced glycation end products; Oxidative stress·综述·doi:10.3969/j.issn.1003-6350.2021.05.029基金项目：贵州省卫生计生委科学技术基金(编号：gzwjkj2017-1-025)