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      标题:神经内镜下经鼻蝶入路切除鞍区病变的颅底重建效果观察
      作者:黄斌,张龙,肖罡,张能,田硕,朱飚,刘保国    韶关市粤北人民医院神经外科,广东 韶关 512000
      卷次: 2021年32卷5期
      【摘要】 目的 探讨神经内镜下经鼻蝶入路切除鞍区病变的颅底重建的效果。方法 回顾性分析韶关市粤北人民医院神经外科2016年11月至2020年6月收治的48例鞍区病变患者的临床资料,其中垂体腺瘤44例,鞍结节脑膜瘤2例,颅咽管瘤2例,所有患者均采用神经内镜下经鼻蝶入路切除鞍区病变,再实施人工硬膜、明胶海绵及生物胶、人工硬膜的“三明治”式修补方法进行颅底重建。观察患者的手术结果及术后随访结果。结果 48例患者中病变完全切除者45例,未完全切除者3例,切除率为93.75%;术后46例患者颅底一次修补成功,2例患者出现短暂性的脑脊液鼻漏,其中术后2 d,有1例患者因球囊破裂而发生脑脊液鼻漏,进行二次修补后已经痊愈,术后1个月,有1例患者因打喷嚏而发生无症状性颅内积气和脑脊液鼻漏,再次行颅底重建后已修复;术后所有患者均未出现严重的并发症,术后随访6个月,患者没有出现脑脊液鼻漏的症状,也没有出现新的神经功能缺失。结论 神经内镜下经鼻蝶入路切除鞍区病变的三明治式颅底重建能明显减少术后患者脑脊液鼻漏的发生,安全性较高,值得临床推广使用。
      【关键词】 鞍区病变;神经内镜;鼻蝶入路;颅底重建;疗效
      【中图分类号】 R651 【文献标识码】 A 【文章编号】 1003—6350(2021)05—0630—03

Effect of skull base reconstruction after resection of sellar lesions under neuroendoscope via nasal sphenoidapproach.

HUANG Bin, ZHANG Long, XIAO Gang, ZHANG Neng, TIAN Shuo, ZHU Biao, LIU Bao-guo. Department ofNeurosurgery, North Guangdong People's Hospital of Shaoguan City, Shaoguan 512000, Guangdong, CHINA
【Abstract】 Objective To investigate the effect of skull base reconstruction after resection of sellar lesions un-der neuroendoscope via nasal sphenoid approach. Methods The clinical data of 48 patients with saddle lesions admit-ted to Department of Neurosurgery, North Guangdong People's Hospital of Shaoguan City from November 2016 to June2020 were retrospectively analyzed, including 44 cases of pituitary adenomas, 2 cases of tuberosity sellar meningioma, 2cases of craniopharyngiomas, All patients underwent neuroendoscopic transnasal transsphenoidal resection of sellar le-sions, and then implement the "sandwich" repair method of artificial dura mater, gelatin sponge, biological glue, and arti-ficial dura mater to reconstruct the skull base. The operative results and postoperative follow-up results were observed.·短篇论著·doi:10.3969/j.issn.1003-6350.2021.05.025基金项目:广东省韶关市卫生健康科研项目(编号:Y20189)

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