标题:超短波联合倍他司汀治疗颈性眩晕的效果及对患者血清VEGF、vWF水平的影响
作者:杨丽英 1,席聪 1,潘延平 2 1.宝鸡市人民医院神经内一科,陕西 宝鸡 721000;2.韩城市人民医院神经内科,陕西 韩城 715400
卷次:
2020年31卷20期
【摘要】 目的 探讨颈性眩晕患者应用超短波及倍他司汀治疗前后眩晕程度及血管内皮生长因子(VEGF)、血管性血友病因子(vWF)含量变化。方法 选取2018年1月至2019年12月宝鸡市人民医院神经内科门诊接诊的100例颈性眩晕患者,简单随机化分为对照A组(n=33)、对照B组(n=33)和观察组(n=34),分别给予倍他司汀、超短波、倍他司汀+超短波治疗,均以2周为一个疗程,连续治疗2个疗程。比较三组患者的治疗效果、不良反应及治疗前后眩晕程度(EVE)、前庭症状指数评分(VSI)、脑干听觉诱发电位检查结果[Ⅰ、Ⅲ、Ⅴ波的潜伏期(PL)、Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ的峰间期(IPL)]、脑血流参数[侧椎动脉(VA)、基底椎动脉(BA)的血管搏动指数(PI)、舒张末期流速(VD)]和血清VEGF、vWF水平。结果 观察组患者的治疗总有效率为94.12%,明显高于对照A组的66.67%和对照B组的69.70%,差异均有统计学意义(P<0.05);治疗后,观察组患者的EVE、VSI评分明显低于对照A组、对照B组,且对照B组明显低于对照A组,差异均有统计学意义(P<0.05);治疗后,三组患者Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ IPL及Ⅰ、Ⅲ、Ⅴ PL比较,差异均无统计学意义(P>0.05);治疗后,三组患者Ⅰ~Ⅲ、Ⅲ~Ⅴ、Ⅰ~Ⅴ IPL及Ⅰ、Ⅲ、Ⅴ PL低于治疗前,差异均有统计学意义(P<0.05);治疗后,观察组患者VA、BA的PI低于对照A组、对照B组,VD高于对照A组、对照B组,且对照B组患者VA、BA的PI低于对照A组,VD高于对照A组,差异均有统计学意义(P<0.05);治疗后,观察组患者血清VEGF水平高于对照A组、对照B组,vWF水平低于对照A组、对照B组,差异均有统计学意义(P<0.05),对照B组患者血清VEGF水平高于对照A组,vWF水平低于对照A组,差异均有统计学意义(P<0.05);三组患者的不良反应比较差异无统计学意义(P>0.05)。结论 超短波联合倍他司汀治疗颈性眩晕患者,可调节VEGF、vWF含量,改善脑血流参数及听觉通路,进而缓解临床症状,疗效显著,且安全性高。
【关键词】 颈性眩晕;超短波;倍他司汀;血管内皮生长因子;血管性血友病因子;脑干听觉诱发电位
【中图分类号】 R441.2 【文献标识码】 A 【文章编号】 1003—6350(2020)20—2627—05
Effect of ultrashort wave combined with betahistine in the treatment of cervical vertigo and its effect on serumVEGF and vWF levels in patients.
YANG Li-ying 1, XI Cong 1, PAN Yan-ping 2. 1. First Department of Neurology, thePeople's Hospital of Baoji City, Baoji 721000, Shaanxi, CHINA; 2. Department of Neurology, the People's Hospital ofHancheng City, Hancheng 715400, Shaanxi, CHINA
【Abstract】 Objective To investigate the changes in the degree of vertigo and the content of vascular endotheli-al growth factor (VEGF) and von Willebrand factor (vWF) before and after treatment with ultrashort wave and betahis-tine in patients with cervical vertigo. Methods A total of 100 patients with cervical vertigo who were admitted to thePeople's Hospital of Baoji City from January 2018 to December 2019 were selected. According to simple randomization,they were divided into control group A (n=33), control group B (n=33), and observation group (n=34). They were givenbetahistine, ultrashort wave, and betahistine+ultrashort wave treatments, each for 2 consecutive courses (2 weeks as acourse of treatment). The treatment effects, adverse reactions, and the degree of vertigo before and after treatment(EVE), vestibular symptom index score (VSI), results of brainstem auditory evoked potentials (the latency [PL] of wavesⅠ,Ⅲ,Ⅴ, the inter-peak period [IPL] ofⅠ-Ⅲ,Ⅲ-Ⅴ,Ⅰ-Ⅴ), cerebral blood flow parameters (vascular pulsatility in-dex [PI] of lateral vertebral artery [VA], basilar vertebral artery [BA], end-diastolic flow velocity [VD]), and serumVEGF and vWF levels were compared among the three groups. Results The total effective rate of treatment in the ob-servation group was 94.12%, which was significantly higher than 66.67% in the control group A and 69.70% in the con-trol group B (P<0.05); after treatment, the EVE and VSI scores of the observation group were significantly lower thanthose of the control group A and control group B (P<0.05), and the score in control group B were significantly lowerthan those in control group A. Before treatment, the IPL ofⅠ-Ⅲ,Ⅲ-Ⅴ,Ⅰ-Ⅴ and the PL ofⅠ,Ⅲ, andⅤ showed nostatistically significant difference among the three groups (P>0.05); after treatment, the IPL ofⅠ-Ⅲ,Ⅲ-Ⅴ,Ⅰ-Ⅴ and
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