标题：VEGF-2578A/C多态性与子宫内膜异位症遗传易感性的Meta分析

      作者：罗加欢 1，张若鹏 2，王惠莹 1，刘浏 1，周宁 1，张媛媛 1    1.大理大学临床医学院，云南 大理 671000；2.大理大学第一附属医院生殖医学科，云南 大理 671000

      卷次： 2020年31卷18期

      【摘要】 目的 评价血管内皮生长因子(VEGF)-2578A/C多态性与子宫内膜异位症(EMT)遗传易感性的相关性。方法 通过检索PubMed、EMbase、中国知网(CNKI)、中国生物医学文献数据库(CBM)和万方数据库中公开发表的有关VEGF-2578A/C多态性与EMT易感性的病例-对照研究，检索时间均为从建库至2019年10月10日。完成筛选文献、提取资料并评价纳入研究的偏倚后，采用Stata14.0软件进行Meta分析。结果 共纳入了7篇病例-对照研究；Meta分析结果示，VEGF-2578A/C多态性与EMT易感性无关联，但异质性较大；根据人种不同进行亚组分析显示：在高加索人人群中等位基因模型(OR=1.278，95%CI：1.021~1.601)、显性模型(OR=1.536，95%CI：1.065~2.216)、杂合子模型(OR=1.528，95%CI：1.098~2.127)会增加 EMT发生的风险，而在亚洲人人群中等位基因模型(OR=0.688，95%CI：0.543~0.871)、显性模型(OR=0.693，95%CI：0.522~0.920)会降低EMT发生的风险。结论 本研究表明VEGF-2578A/C突变在高加索人人群中是EMT的易感因素，在亚洲人人群则为EMT的保护因素。
      【关键词】 血管内皮生长因子；多态性；子宫内膜异位症；遗传易感性；Meta分析；
      【中图分类号】 R711.74 【文献标识码】 A 【文章编号】 1003—6350（2020）18—2433—05

Association between VEGF-2578A/C gene polymorphisms and the genetic susceptibility to endometriosis: ameta-analysis.
LUO Jia-huan 1, ZHANG Ruo-peng 2, WANG Hui-ying 1, LIU Liu 1, ZHOU Ning 1, ZHANG Yuan-yuan 1.1. Clinical Medical College, Dali University, Dali 671000, Yunnan, CHINA; 2. Department of Reproductive Medicine, theFirst Affiliated Hospital of Dali University, Dali 671000, Yunnan, CHINA
【Abstract】 Objective To systematically review the correlation between vascular endothelial growth factor(VEGF)-2578A/C polymorphism and endometriosis (EMT) susceptibility by meta-analysis. Methods PubMed, EM-BASE, CNKI, CBM and Wanfang databases were electronically searched to collect case-control studies on the correla-tion between VEGF-2578A/C polymorphism and endometriosis susceptibility from inception to October 10, 2019. Af-ter screening literatures, extracting data and evaluating the bias of the included studies, meta-analysis was performedby using Stata 14.0 software. Results A total of 7 case-control studies were included. The results of meta analysisshowed that there is no correlation between VEGF-2578A/C with endometriosis susceptibility. Due to the heterogene-ity is relatively large, subgroup analysis based on ethnicity showed that in Caucasian population, Allele model (OR=1.278, 95%CI:1.021-1.601), dominant model (OR=1.536, 95%CI: 1.065-2.216), and heterozygote model (OR=1.528,95%CI: 1.098-2.127) increased the risk of EMT, whereas allele model (OR=0.688, 95%CI: 0.543-0.871), and dominantmodel (OR=0.693, 95%CI: 0.522-0.920) would reduce the risk of EMT in Asian population. Conclusion This studyshowed that the VEGF-2578A/C mutation was a susceptible factor for EMT in Caucasian population, but a protectivefactor for EMT in Asian population.
      【Key words】 Vascular endothelial growth factor (VEGF); Polymorphism; Endometriosis (EMT); Genetic suscep-tibility; Meta-analysis·荟萃分析·doi:10.3969/j.issn.1003-6350.2020.18.035基金项目：国家自然科学基金(编号：81860271)；云南省地方本科高校基础研究联合专项项目(编号：2017FH001-078)；云南省医学学科带头人培养对象项目(编号：D-2017020)；云南省“万人计划”名医专硕人才项目(编号：云卫人发[2019]35号)；大理大学第八批中青年学术带头人后备人才项目(编号：理大研发[2017]2号)；大理大学第一附属医院第二批院级重点学(专)科建设项目(编号：大附院[2016]46号)；大理大学生殖医学创新团队项目(编号：ZKLX2019320)