标题：夜宵食用人群机体代谢状况的横断面调查研究

      作者：王欣 1，许怡 1，余逸菲 1，王唯坚 1，王芳 1，辛鑫 1，胡义扬 1,2,3，冯琴 1,2,3    1.上海中医药大学附属曙光医院肝病研究所，上海 201203；2.上海市中医临床重点实验室，上海 201203；3.肝肾疾病病证教育部重点实验室，上海 201203

      卷次： 2020年31卷18期

      【摘要】 目的 分析夜宵食用人群与非食用夜宵人群机体代谢状况的差异，探讨食用夜宵对机体代谢的影响。方法 选取上海中医药大学附属曙光医院体检中心2018年1月至2019年5月共286名体检者，采用问卷形式调查夜宵食用情况，并收集身高、体质量、腰围、体质量指数(BMI)等基本信息及空腹血糖、血脂、肝功能、尿酸及腹部B超脂肪肝患病情况；根据夜宵进食与否将调查人群分为进食夜宵组及非进食夜宵组，比较两组人群的体质量、血糖、血脂、肝功能、尿酸、脂肪肝患病率等机体代谢相关指标。结果 进食夜宵组人群的体质量为(74.14±14.14) kg，明显高于非进食夜宵组的(70.54±14.01) kg，差异具有统计学意义(P<0.05)；腰围中位数83 cm，明显高于非进食夜宵组的 77 cm，BMI为(25.02±4.04) kg/m2，明显高于非进食夜宵组的(23.93±3.03) kg/m2，差异均有统计学意义(P<0.05)；进食夜宵组人群的血清尿酸含量、血清丙氨酸氨基转移酶(ALT)活性、天冬氨酸转氨酶(AST)活性均明显高于非进食夜宵组，差异均有统计学意义(P<0.05)；进食夜宵组人群的脂肪肝患病率为49.66%，明显高于非进食夜宵组的36.88%，差异具有统计学意义(P<0.05)；进食夜宵组人群的空腹血糖与非进食夜宵组比较差异无统计学意义(P>0.05)；进食夜宵组人群的血清甘油三酯(TG)、胆固醇(TC)含量与非进食夜宵组相比有升高趋势，但差异无统计学意义(P>0.05)；进食夜宵人群夜宵种类以烧烤海鲜类(50.3%)、甜点类(40.0%)、含糖饮料类(35.9%)为主。结论 进食夜宵可促进体质量增加、尿酸代谢异常及脂肪肝患病风险，可能是机体代谢紊乱的重要危险因素。
      【关键词】 夜宵；代谢；非酒精性脂肪性肝病；肝功能；血糖；健康教育
      【中图分类号】 R155.1 【文献标识码】 D 【文章编号】 1003—6350（2020）18—2426—03

Across-sectional study on the metabolic status among adults of night eating.
WANG Xin 1, XU Yi 1, YU Yi-fei 1,WANG Wei-jian 1, WANG Fang 1, XIN Xin 1, HU Yi-yang 1,2,3, FENG Qin 1,2,3. 1. Shuguang Hospital & Institute ofHepatology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, CHINA; 2. Shanghai Key ClinicalLaboratory of Traditional Chinese Medicine, Shanghai 201203, CHINA; 3. Key Laboratory of Liver and Kidney Diseases,Ministry of Education, Shanghai 201203, CHINA
【Abstract】 Objective To analyze the difference in metabolism between adults of night eating and those not ofnight eating, to investigate the possible influence of night eating on metabolism. Methods A total of 286 adults withphysical examination in Shuguang Hospital & Institute of Hepatology, Shanghai University of Traditional Chinese Medi-cine from January 2018 to May 2019 were selected, and questionnaires were used to investigate the status of night eat-ing. Basic information such as height, weight, waist size, and body mass index (BMI) were collected, and blood glucose,triglyceride, liver function, uric acid, abdominal ultrasound were detected. According to the night eating or not, adultswith physical examination were divided into the nighttime eating group and non-nighttime eating group, and the height,blood glucose, triglyceride, liver function, uric acid, fatty liver disease rate and other metabolic related indicators werecompared. Results The weight of the people in the night eating group was (74.14±14.14) kg, which was significantlyhigher than (70.54±14.01) kg of the non-night eating group (P<0.05); the median waist circumference was 83 cm, whichwas significantly higher than 77 cm of the non-night eating group (P<0.05); BMI was (23.93±3.03) kg/m2, which wassignificantly higher than (25.02±4.04) kg/m2 of the non-night eating group (P<0.05). Serum uric acid content, serum glu-tamate pyruvate transaminase (ALT) activity, aspartate aminotransferase (AST) activity were significantly higher thanthose in the non-night eating group (all P<0.05); the prevalence of fatty liver in the night eating group was 49.66% ver-sus 36.88% of the non-nigh eating group (P<0.05); there was no significant difference between fasting blood glucose inthe two groups (P>0.05). Serum triglyceride and total cholesterol (TC) in the night eating group were increased, but itwas not statistically significant (P>0.05). The main types of late-night snacks for late-night eaters were barbecued sea-food (50.3%), desserts (40%), and sugary drinks (35.9%). Conclusion Night eating can increase weight and the risk ofnonalcoholic fatty liver disease (NAFLD), and cause abnormal uric acid metabolism, which might be an important riskfactor of metabolic disorders.
      【Key words】 Night eating; Metabolism; Nonalcoholic fatty liver disease (NAFLD); Liver function; Glucose;Health education·调查研究·doi:10.3969/j.issn.1003-6350.2020.18.033基金项目：国家自然科学基金重点项目(编号：81830119)；国家科技重大专项“重大新药创制”项目(编号：2019ZX09201001-001-002)；上海市科委科技支撑计划(编号：19401972100)；上海市科委科技创新行动计划项目(编号：18401933100)