标题：胃蛋白酶原、胃泌素-17和幽门螺杆菌抗体在早期胃癌筛查中的研究进展

      作者：黄学 综述 刘福健，贾秋红 审校    广西医科大学第八附属医院消化内科，广西 贵港 537100

      卷次： 2020年31卷18期

      【摘要】 早期胃癌的诊断主要通过胃镜筛查，但胃镜是一种侵入性检查，很多患者不能接受，故限制了胃镜在胃癌大规模筛查中的应用。日本等发达国家应用血清胃蛋白酶原、抗幽门螺旋杆菌抗体等对全民进行胃癌筛查后，取得很好的效果。“发现一例早癌，挽救一条生命，幸福一个家庭”，为提高我国早期胃癌的诊断率，我国近年来采用检测血清胃蛋白酶原、胃泌素-17、抗幽门螺旋杆菌抗体等进行胃癌初步筛查，取得一定效果。但目前适用于我国胃癌大规模筛查的方法仍需进一步研究。因此，本文就早期胃癌筛查的重要性、胃癌的筛查对象、胃蛋白酶原及胃泌素-17等在早期胃癌筛查中的研究做一综述。
      【关键词】 胃蛋白酶原；胃泌素-17；幽门螺旋杆菌；早期胃癌；胃癌筛查；研究进展
      【中图分类号】 R735.2 【文献标识码】 A 【文章编号】 1003—6350（2020）18—2414—05

Progress of pepsinogen, gastrin-17, and Helicobacter pylori antibodies in early gastric cancer screening.
HUANGXue, LIU Fu-jian, JIA Qiu-hong. Department of Gastroenterology, the Eighth Affiliated Hospital of Guangxi MedicalUniversity, Guigang 537100, Guangxi, CHINA【Abstract】 The diagnosis of early gastric cancer is mainly through gastroscopy. Gastroscopy is an invasive ex-amination, which cannot be accepted by many patients, so the application of gastroscopy in large-scale screening of gas-tric cancer is limited. In Japan and other developed countries, serum pepsinogen and anti-Helicobacter pylori antibodieswere used to screen the whole population for gastric cancer, and good results were obtained. With the philosophy of "dis-cover an early cancer case, save a life, happy a family", and the goal of“to improve the diagnosis rate of early gastriccancer in China”, the detection of serum pepsinogen, gastrin-17, and anti-Helicobacter pylori antibodies have been usedin the preliminary screening of gastric cancer in recent years in China, and some achievements have been reached. Themethod suitable for large-scale screening of gastric cancer in China still needs further study. Therefore, this article re-views the importance of early gastric cancer screening, the targets of gastric cancer screening, pepsinogen, and gas-trin-17 in early gastric cancer screening.
      【Key words】 Pepsinogen; Gastrin-17; Helicobacter pylori; Early gastric cancer; Gastric cancer screening; Progress·综述·doi:10.3969/j.issn.1003-6350.2020.18.030基金项目：广西贵港市科技局项目(编号：贵科转1607014、贵科转1803007)