标题：结肠慢传输型便秘的研究进展

      作者：陈容 综述 周泠 审校    遵义医科大学附属医院，贵州 遵义 563000

      卷次： 2020年31卷18期

      【摘要】 慢传输型便秘(STC)是日益增多的一种临床慢性消化道症状，是慢性便秘中最为常见的类型。结肠蠕动减慢、传输能力减弱是其独特的特点；主要表现为排便周期和时间延长、排便费力、粪质干结，病情反复发作，难以治愈。便秘流行病学研究困难，病因病机尚不完全明确，故笔者总结临床经验及基础实验研究：把促进胃肠道动力、调节肠神经系统、平衡Cajal间质细胞的数量、维持肠道菌群平衡等作为有效作用靶点，使患者生活质量得以提高，促进治疗STC药物的开发。本文就STC的发病机制和治疗方法进行综述。
      【关键词】 结肠慢传输型便秘；继发疾病；病机；药物；手术；疗效；研究进展
      【中图分类号】 R442.2 【文献标识码】 A 【文章编号】 1003—6350（2020）18—2409—05

Research progress of colon slow transit constipation.
CHEN Rong, ZHOU Ling. The Affiliated Hospital of ZunyiMedical University, Zunyi 563000, Guizhou, CHINA【Abstract】 Slow-transit constipation (STC) is an increasing clinical chronic gastrointestinal symptom, which isthe most common type of chronic constipation. Slowed colonic peristalsis and weakened transmission capacity are itsunique characteristics. The main manifestations are prolonged defecation cycle and time, laborious defecation, fecal dryknot, repeated attacks, and difficulties to cure. The epidemiological study of constipation is difficult, and the etiologyand pathogenesis are not completely clear. Clinical experience and basic experimental research take the following itemsas the effective target: promote gastrointestinal motility, adjust enteric nervous system, balance the number of interstitialcells of Cajal, maintain the balance of intestinal flora to improve the quality of life of patients and promote the develop-ment of STC drugs. This article reviews the pathogenesis and treatment of STC.
      【Key words】 Slow-transit constipation (STC); Secondary diseases; Pathogenesis; Drugs; Surgery; Efficacy; Re-search progress·综述·doi:10.3969/j.issn.1003-6350.2020.18.029基金项目：贵州省科技厅联合基金项目(编号：CH120160396)