标题：BAMBI通过Wnt通路参与相关疾病发生发展的研究进展

      作者：贾哲 1，于祥远 1，陈斐然 1，杨文文 1，刘创萍 1 综述 秦胜花 2 审校    1.桂林医学院，广西 桂林 541001；2.桂林市人民医院健康管理中心，广西 桂林 541001

      卷次： 2020年31卷18期

      【摘要】 骨形态发生蛋白和激活素膜结合抑制剂(BAMBI)是TGF超家族信号通路的伪受体，在机体细胞生长等多个生理病理过程中发挥重要的调控作用。Wnt信号通路在细胞水平上参与细胞增殖和分化，在组织水平上参与胚胎发育和分化，在机体中发挥重要作用。相关研究表明，BAMBI可通过Wnt信号通路促进肿瘤的形成和侵袭，促进细胞分化，如促进子宫滋养细胞分化，维持正常妊娠，促进肌肉组织和血管的形成；而与上述结论相反，BAMBI可通过Wnt信号通路抑制肥胖的形成。
      【关键词】 骨形态发生蛋白和激活素膜结合抑制剂；Wnt信号通路；肿瘤；肥胖；胚胎分化
      【中图分类号】 R363.2 【文献标识码】 A 【文章编号】 1003—6350（2020）18—2402—04

Research progress of BAMBI participating in the occurrence and development of related diseases through Wntpathway.
JIA Zhe 1, YU Xiang-yuan 1, CHEN Fei-ran 1, YANG Wen-wen 1, LIU Chuang-ping 1, QIN Sheng-hua 2. 1. GuilinMedical University, Guilin 541001, Guangxi, CHINA; 2. Health Management Center, Guilin People's Hospital, Guilin541001, Guangxi, CHINA【Abstract】 BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) is a pseudo-receptor ofTGF superfamily signaling pathway and plays an important regulatory role in multiple physiological and pathologicalprocesses such as cell growth. The Wnt signaling pathway is involved in cell proliferation and differentiation at the cellu-lar level and involved in embryonic development and differentiation at the tissue level, playing an important role in theorganism. Relevant studies have shown that BAMBI can promote tumor formation and invasion through Wnt signalingpathway, promote cell differentiation, such as promoting uterine trophoblastic cell differentiation, maintaining normalpregnancy, and promoting the formation of muscle tissue and blood vessels. Contrary to the above conclusions, BAMBIcan inhibit the formation of obesity through the Wnt signaling pathway.
      【Key words】 BAMBI; Wnt signaling pathway; Tumor; Obesity; Embryo differentiation·综述·doi:10.3969/j.issn.1003-6350.2020.18.027基金项目：广西自然科学基金(编号：2016JJA140305)；广西高校大学生创新创业计划项(编号：201810601004)