标题：角膜胶原交联术的应用与研究进展

      作者：张婧 综述 刘太祥 审校    遵义医科大学附属医院，贵州 遵义 563000

      卷次： 2020年31卷18期

      【摘要】 近年来，随着诊疗技术的应用及角膜屈光手术的开展，圆锥角膜、大泡性角膜病变及屈光手术导致的医源性角膜扩张、感染性角膜炎等患病率呈上升趋势，但传统的药物治疗疗效差，手术治疗供体紧张且操作难度高，不能满足临床工作需求。而角膜胶原交联作为交联技术在医学领域中新兴的应用手段，为解决这一临床难题带来了新的希望。现就目前角膜胶原交联术的研究现状展开综述。
      【关键词】 胶原交联；核黄素；紫外线-A；圆锥角膜；感染性角膜炎；角膜生物力学
      【中图分类号】 R772.2 【文献标识码】 A 【文章编号】 1003—6350（2020）18—2399—04

Application and research progress of corneal collagen cross-linking.
ZHANG Jing, LIU Tai-xiang. The AffiliatedHospital of Zunyi Medical University, Zunyi 563000, Guizhou, CHINA【Abstract】 In recent years, with the application of diagnosis and treatment technology and the development ofcorneal refractive surgery, the prevalence of keratoconus, bullae keratopathy and iatrogenic keratectasia and infectiouskeratitis caused by refractive surgery are on the rise. Traditional drug therapy has a poor curative effect, and the surgicaltreatment of donor is tight and difficult to operate, which cannot meet the needs of clinical work. Corneal collagencross-linking, as a new method of cross-linking technology applied in medical field, brings a new hope to solve this diffi-cult clinical problem. This paper reviews the current research status of corneal collagen cross-linking.
      【Key words】 Collagen cross-linking; Riboflavin; Ultraviolet-A; Keratoconus; Infectious keratitis; Corneal biome-chanics·综述·doi:10.3969/j.issn.1003-6350.2020.18.026基金项目：国家自然科学基金(编号：81960183)