标题：屈光参差性弱视患儿视力损害与皮层功能的关系

      作者：张丹 1，胡俊喜 2，王瑞珠 3    1.西安普瑞眼科医院眼科，陕西 西安 710003；2.新乡医学院第一附属医院眼科，河南 新乡 453100；3.郑州普瑞眼科医院眼科，河南 郑州 450000

      卷次： 2020年31卷17期

      【摘要】 目的 探讨屈光参差性弱视患儿视力损害与皮层功能的关系。方法 将2017年6月至2019年7月西安普瑞眼科医院收治的 70例屈光参差性弱视患儿作为疾病组，选取同期视力检查正常的 70例儿童作为健康组。分析并比较两组患儿的磁共振成像(fMRI)检查结果，根据视力损害程度分为轻度组(n=18)、中度组(n=42)和重度组(n=10)，采用Spearman秩相关分析 fMRI检查结果与视力损害程度之间的关系。结果 疾病组患儿弱视眼和健康眼对应的脑部皮层激活强度分别为(3.60±0.38)×103、(4.85±0.44)×103体素，明显低于健康组[(4.84±0.49)×103、(5.98±0.62)×103体素]，差异均有统计学意义(P<0.05)；疾病组中，轻度组患儿弱视眼和健康眼脑部视觉皮层激活强度分别为(4.16±0.49)×103、(5.27±0.66)×103体素，中度组分别为(3.87±0.32)×103、(4.96±0.47)×103体素，重度组分别为(3.37±0.31)×103、(4.61±0.42)×103体素，重度组双眼脑部视觉皮层激活强度低于轻度组和中度组，中度组双眼脑部视觉皮层激活强度低于轻度组，差异均有统计学意义(P<0.05)；经Spearman秩相关分析，疾病组患儿视觉皮层激活强度与视力损害程度无相关性(r=0.144，P=0.285)。结论 视力正常儿童双眼视觉皮层激活强度均高于屈光参差性弱视患儿的弱视眼和健康眼，患儿视觉皮层激活强度与视力损害程度无显著相关性。
      【关键词】 弱视；视力损害；皮层功能；功能磁共振；屈光参差性
      【中图分类号】 R778 【文献标识码】 A 【文章编号】 1003—6350（2020）17—2239—04

Relationship between visual impairment and cortical function in children with anisometropic amblyopia.
ZHANGDan 1, HU Jun-xi 2, WANG Rui-zhu 3. 1. Department of Ophthalmology, the Purui Eye Hospital of Xi'an, Xi'an 710003,Shaanxi, CHINA; 2. Department of Ophthalmology, the First Affiliated Hospital of Xinxiang Medical College, Xinxiang453100, Henan, CHINA; 3. Department of Ophthalmology, the Purui Eye Hospital of Zhengzhou, Zhengzhou 450000,Henan, CHINA
【Abstract】 Objective To explore the relationship between visual impairment and cortical function in childrenwith anisometropic amblyopia (AA). Methods Seventy children with AA admitted to the Purui Eye Hospital of Xi'anfrom June 2017 to July 2019 were enrolled as disease group. Seventy normal children who underwent visual inspectionduring the same period were enrolled as healthy group. The results of functional magnetic resonance imaging (fMRI) inboth groups were analyzed and compared. According to visual impairment degree, the patients were divided into mildgroup (n=18), moderate group (n=42), and severe group (n=10). The relationship between fMRI results and visual impair-ment degree was analyzed by Spearman rank analysis. Results The activation intensities of cerebral cortex correspond-ing to amblyopia and healthy eyes in disease group were (3.60±0.38)×103 and (4.85±0.44)×103 voxels, significantly lower