标题：2型糖尿病患者血清 sCD40L与颈动脉粥样硬化的相关性

      作者：王永翠，刘昌盛，薄通文?
    （莒南县人民医院内分泌科，山东 莒南 276600）

      卷次： 2013年24卷1期

      【摘要】 目的 探讨 2型糖尿病患者中血清可溶性CD40配体(sCD40L)水平与颈动脉粥样硬化的关系。
方法 患者分为 2型糖尿病组（DM组）64例和正常对照组（NC组）56例，比较两组的生化指标、糖化血红蛋白
(HbA1c)、血清 sCD40L水平、颈动脉内-中膜厚度（IMT）和Crouse斑块积分等。结果 DM组血清 sCD40L水
平、IMT、Crouse积分明显高于NC组(P<0.05)，sCD40L与 IMT、Crouse积分、HbA1c、TG呈显著正相关(P<0.05)。
结论 sCD40L在2型糖尿病动脉粥样硬化中起重要的作用。

      【关键词】 2型糖尿病；sCD40L；动脉硬化

      【中图分类号】 R587.1 【文献标识码】 A 【文章编号】 1003—6350(2013)01—0016—02


Correlation between serum solube CD40 ligand and carotid atherosclerosis in patients with type 2 diabetes
mellitus.
WANG Yong-cui, LIU Chang-sheng, BO Tong-wen. Department of Endocrinology, People Hospital of Junan
County, Junan 276600, Shandong, CHINA

【Abstract】 Objective To investigate the relationship between serum solube CD40 ligand (sCD40L) and ca-
rotid atherosclerosis in patients with type 2 diabetes mellitus. Methods Sixty-four patients with type 2 diabetes melli-
tus (the DM group) and 56 healthy individuals (the control group) were compared in terms of the serum levels of
sCD40L, carotid intima Media Thickness (IMT) and Crouse score. Results The serum levels of sCD40L, IMT, and
Crouse score were all significantly higher in the DM group than the control group (P<0.05). The level of sCD40L was
positively related with IMT, Crouse score, HbA1c and TG. Conclusion sCD40L plays an important role in the pro-
gression of atherosclerosis.

      【Key words】 Type 2 diabetic mellitus; sCD40L; Atherosclerosis