标题：外泌体对巨噬细胞极化调控的相关研究进展

      作者：李斌斌 综述 张良清 审校    广东医科大学附属医院麻醉科，广东 湛江 524000

      卷次： 2020年31卷16期

      【摘要】 外泌体作为细胞间关键的沟通工具，参与机体各种生理过程以及病理发展当中，巨噬细胞极化分为M1促炎亚型以及M2抗炎亚型，许多文献已证明巨噬细胞的极化状态对疾病的进展转归发挥着调控作用。本文就外泌体如何参与巨噬细胞表型改变及其影响进行综述，叙述在不同器官疾病当中，外泌体调控巨噬细胞极化的分子机制，为该领域的研究提供更充分的理论依据。
      【关键词】 外泌体；巨噬细胞；极化；分子机制；肿瘤；神经系统疾病；心血管疾病；代谢性疾病；肾脏疾病；肝脏疾病
      【中图分类号】 R329.2 【文献标识码】 A 【文章编号】 1003—6350（2020）16—2133—04

Research progress of the regulatory of exosomes on macrophage polarization.
LI Bin-bin, ZHANG Liang-qing.Department of Anesthesiology, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong,CHINA【Abstract】 Exosomes, as a key tool for intercellular communication, participate in various physiological process-es and pathological development of the body. Macrophage polarization is divided into M1 pro-inflammatory subtype andM2 anti-inflammatory subtype. Many literatures have proved that the polarization of macrophage plays a regulatory rolein the progression of the disease. In this paper, how exosomes affect the phenotypic changes of macrophage and their ef-fects in different organ diseases are discussed in detail. The molecular mechanism of exosomes regulating macrophagepolarization will provide more sufficient theoretical basis for the research in this field.
      【Key words】 Exosome; Macrophage; Polarization; Molecular mechanism; Tumor; Nervous system diseases; Car-diovascular diseases; Metabolic diseases; Kidney diseases; Liver diseases·综述·doi:10.3969/j.issn.1003-6350.2020.16.026