标题：COX-2与肝癌关系研究的新进展

      作者：赵晓瑾 1，朱佳斌 2 综述 尚发军 2 审校    三峡大学附属仁和医院消化内科 1、神经外科 2，湖北 宜昌 443000

      卷次： 2020年31卷16期

      【摘要】 肝癌是最常见的原发性肝肿瘤，其发生与乙肝病毒或丙肝病毒感染因素有关，但确切的发病机制尚不明确。目前临床上对于肝癌主要采用手术、局部治疗和肝移植等综合疗法，但预后差，肝癌患者的五年生存率仍小于8%。很多研究表明环加氧酶-2 (COX-2)在肝癌发生中起重要作用，COX-2特异性抑制剂能够有效抑制肝癌的增殖和侵袭迁移。这些发现为肝癌的防治提供了新的思路。本文就COX-2与肝癌的关系做一概述。
      【关键词】 环加氧酶-2；肝癌；增殖；侵袭；迁移；进展
      【中图分类号】 R735.7 【文献标识码】 A 【文章编号】 1003—6350（2020）16—2129—04

Relationship between COX-2 and hepatocellular carcinoma.
ZHAO Xiao-jin 1, ZHU Jia-bin 2, SHANG Fa-jun 2.Department of Gastroenterology 1, Department of Neurosurgery 2, Affiliated Renhe Hospital of China Three Gorges University,Yichang 443000, Hubei, CHINA【Abstract】 Hepatocellular carcinoma is the most common primary liver tumor, and its occurrence is most close-ly linked to hepatitis B virus or hepatitis C virus infection, but the exact pathogenesis is still unclear. Clinically, hepato-cellular carcinoma is mainly treated with surgical resection, local treatment and liver transplantation, but the prognosis ispoor. The five-year survival rate of hepatocellular carcinoma patients is still less than 8%. Many studies have shown thatcyclooxygenase-2 (COX-2) plays an important role in the development of hepatocellular carcinoma. COX-2 specific in-hibitors can effectively inhibit the proliferation and invasion and migration of hepatocellular carcinoma. These findingsprovide new ideas for the prevention and treatment of hepatocellular carcinoma. This article provides an overview of therelationship between COX-2 and hepatocellular carcinoma.
      【Key words】 Cyclooxygenase-2 (COX-2); Hepatocellular carcinoma; Proliferation; Invasion; Migration; Re-search progress·综述·doi:10.3969/j.issn.1003-6350.2020.16.025基金项目：湖北省卫生健康科研基金(编号：WJ2019H544、WJ2019H557)；肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学)项目(编号：2019KZL07)