标题：不同喂养方式对先天性巨细胞病毒感染新生儿病毒载量的影响

      作者：杨洋 1，王春晖 1，王宝西 1，王琳 2    1.空军军医大学第二附属医院儿科，陕西 西安 710038；2.长安医院儿科，陕西 西安 710016

      卷次： 2020年31卷16期

      【摘要】 目的 探讨母乳喂养与人工喂养对先天性巨细胞病毒(CMV)感染新生儿病毒载量的影响。方法 选择2016年 7月至 2019年 6月空军军医大学第二附属医院儿科诊治的 82例CMV感染无症状新生儿为研究对象，根据喂养方式的不同将其分为两组，其中 31例采用母乳喂养者为观察组，51例采用人工喂养者对照组。比较两组新生儿唾液/尿液CMV DNA载量的差异，并随访至出生后 6个月，观察两组新生儿的肝功能异常和脑发育异常情况。结果 观察组和对照组新生儿的CMV DNA病毒载量出生 3 d内[(2.62±0.51) vs (2.51±0.62)]、1个月[(1.85±0.95) vs (1.92±0.73)]、3个月[(1.82±0.92) vs (1.71±0.75)]、6个月[(1.69±0.62) vs (1.62±0.53)]比较差异均无统计学意义(P>0.05)；所有新生儿均获得随访，观察组与对照组新生儿的肝功能异常(3.23% vs 0)、脑发育异常(0 vs0)、中性细胞减少(3.23% vs 0)、贫血(3.23% vs 0)、听力异常(6.45% vs 1.96%)检出率比较差异均无统计学意义(P>0.05)。结论 乳汁CMV阳性母乳喂养并不增加无症状CMV感染新生儿CMV病毒载量，亦不增加继发CMV感染风险。
      【关键词】 先天性巨细胞病毒；感染；母乳喂养；人工喂养；病毒载量
      【中图分类号】 R722.13 【文献标识码】 A 【文章编号】 1003—6350（2020）16—2105—03

Effect of different feeding methods on viral load of neonates infected with congenital cytomegalovirus.
YANG Yang 1,WANG Chun-hui 1, WANG Bao-xi 1, WANG Lin 2. 1. Department of Pediatrics, the Second Affiliated Hospital of Air ForceMilitary Medical University, Xi'an 710038, Shaanxi, CHINA; 2.Department of Pediatrics, Chang'an Hospital, Xi'an 710016,Shaanxi, CHINA
【Abstract】 Objective To investigate the effect of breast-feeding and artificial feeding on viral load of neonatesinfected with congenital cytomegalovirus (CMV). Methods A total of 82 asymptomatic neonates with CMV infectiondiagnosed and treated in the Second Affiliated Hospital of PLA Military Medical University from July 2016 to June 2019were selected as the study objects. According to the different feeding methods, they were divided into two groups: the ob-servation group (31 cases) were breast fed, and the control group (51 cases) were artificial fed. The difference of CMVDNA load in saliva/urine between the two groups were observed and followed up to 6 months after birth. The abnormalliver function and abnormal brain development between the two groups of neonates were observed. Results There wasno significant difference in CMV DNA viral load between the observation group and the control group within 3 days,1 month, 3 months and 6 months after birth: (2.62±0.51) vs (2.51±0.62), (1.85±0.95) vs (1.92±0.73), (1.82±0.92) vs (1.71±0.75), (1.69±0.62) vs (1.62±0.53), P>0.05. All newborns were followed up. There was no significant difference in the de-tection rate between the observation group and the control group for abnormal liver function (3.23% vs 0), brain develop-ment abnormality (0 vs 0), neutropenia (3.23% vs 0), anemia (3.23% vs 0), hearing abnormality (6.45% vs 1.96%), P>0.05. Conclusion CMV positive breast feeding does not increase the viral load of CMV in asymptomatic CMV infect-ed newborns, and does not increase the risk of CMV infection.
      【Key words】 Congenital cytomegalovirus (CMV); Infection; Breast feeding; Artificial feeding; Viral load