标题：尼莫地平联合依达拉奉治疗蛛网膜下腔出血的疗效观察

      作者：及其对S100蛋白的影响
    黄其军，陈宏刚
（德阳市第二人民医院神经外科，四川 德阳 618000）

      卷次： 2013年24卷1期

      【摘要】 目的 探讨尼莫地平联合依达拉奉治疗蛛网膜下腔出血(SAH)的疗效及其对S100蛋白的影响。
方法 共纳入60例蛛网膜下腔出血患者，采用随机数字法平均分为两组，A组给予尼莫地平联合依达拉奉治疗；
B组单独给予尼莫地平治疗。所有患者均观察其疗效，并于治疗前及治疗后1 d、3 d、7 d、14 d空腹抽取肘静脉血
检测 S100蛋白的水平。结果 治疗 14 d后两组间疗效比较，A组明显优于 B组，总有效率分别为 93.3%及
83.3%，差异有统计学意义（P<0.05）。治疗前两组S100蛋白水平差异无统计学意义（P>0.05）；与治疗前相比，治
疗后1 d、3 d、7 d、14 d两组患者血浆S100蛋白水平均明显增高，差异有统计学意义（P<0.05）；但A组低于B组，差
异有统计学意义（P<0.05）。治疗后两组间预后比较，A组明显优于B组，差异有统计学意义（P<0.05）。结论 尼
莫地平联合依达拉奉治疗SAH不仅有明显的疗效，还能有效提高患者的预后效果，有效降低氧自由基的水平，提
高患者的康复水平。

      【关键词】 尼莫地平；依达拉奉；蛛网膜下腔出血；S100

      【中图分类号】 R743.35 【文献标识码】 A 【文章编号】 1003—6350(2013)01—0013—03


Clinical effect of nimodipine combined with edaravone in the treatment of subarachnoid hemorrhage and their
effect on S100 protein.
HUANG Qi-jun, CHEN Hong-gang. Department of Neurosurery, the Second People's Hospital of
Deyang City, Deyang 618000, Sichuan, CHINA

【Abstract】 Objective To investigate the clinical effect of nimodipine combined with edaravone in the treat-
ment of subarachnoid hemorrhage and their effect on S100 protein. Methods Sixty patients with subarachnoid hem-
orrhage were divided into two groups by random number method: group A (treated by nimodipine combined with edar-
avone), group B (treated by nimodipine alone). The clinical efficacy was observed in all the patients. The levels of
S100 protein were detected before treatment, and 1 d, 3 d, 7 d, 14 d after treatment by hollow extraction cubits venous
blood test. Results 14 d after treatment, the clinical effect was significantly better in group A than group B, with
the total effective rate of 93.3% and 83.3%, respectively (P<0.05). The S100 levels showed no statistically signifi-
cant difference before treatment between the two groups (P>0.05). Compared with before treatment, the S100 levels
1 d, 3 d, 7 d, 14 d after treatment were significantly increased in both the two groups (P<0.05), and the levels was
significantly lower in group A than group B (P<0.05). The prognosis after treatment was significantly better in
group A than group B (P<0.05). Conclusion Nimodipine combined with edaravone not only have obvious curative
effect for SAH, but also effectively improve the prognosis, reduce the levels of oxygen radicals, and improve the re-
covery level of patients.

      【Key words】 Nimodipine; Edaravone; Subarachnoid hemorrhage; S100