标题：卡马西平对癫痫患者血同型半胱氨酸、叶酸、维生素B12水平的影响

      作者：张其梅，夏 杰，张建宇
    (三峡大学第一临床医学院宜昌市中心人民医院神经内科，湖北 宜昌 443003)

      卷次： 2013年24卷1期

      【摘要】 目的 探讨卡马西平(Carbamazepine，CBZ)对血同型半胱氨酸(Homocysteine，Hcy)、叶酸、维生素
B12 (vitaminB12，VitB12)水平的影响。方法 分别检测CBZ单药治疗癫痫患者(CBZ组)的血Hcy、叶酸、VitB12水平，
并与未服用抗癫痫药的患者(癫痫对照组)及健康对照组进行比较。结果 CBZ组患者血Hcy水平明显高于癫
痫对照组和正常对照组(P<0.01)，叶酸水平低于癫痫对照组和正常对照组(P<0.05)，VitB12水平有下降趋势，但与
两对照组比较，差异无统计学意义(P>0.05)。结论 CBZ可引起癫痫患者血Hcy水平升高和叶酸水平降低；长期
服用CBZ的癫痫患者应监测血Hcy、叶酸、VitB12浓度，及时补充叶酸和B族维生素，以预防血栓事件的发生。

      【关键词】 卡马西平；癫痫；同型半胱氨酸；叶酸；维生素B12

      【中图分类号】 R742.1 【文献标识码】 A 【文章编号】 1003—6350(2013)01—0011—02


Effect of carbamazepine on the levels of homocysteine, folic acid, vitamin B12 in patients with epilepsy.
ZHANG
Qi-mei, XIA Jie, ZHANG Jian-yu. Department of Neurology, the Central People's Hospital of Yichang City, the First
Clinical Medical College of Three Gorges University, Yichang 443003, Hubei, CHINA

【Abstract】 Objective To investigate the effect of carbamazepine (CBZ) on the levels of homocysteine
(Hcy), folic acid, vitamin B12 (VitB12). Methods The levels of blood Hcy, folic acid, VitB12 were measured in epilep-
sy patients treated by CBZ (CBZ group), epilepsy patients not treated by CBZ (the epilepsy control group), healthy in-
dividuals (the normal control group). The results were compared between the three groups. Results The blood Hcy
levels in CBZ group were significantly higher than those in the epilepsy control group and the normal control group
(P<0.01), while the levels of folic acid were significantly lower (P<0.05). The levels of VitB12 exhibited a downward
trend in CBZ group, but showed no statistically significant difference with the other two groups. Conclusion CBZ
can elevate the levels of Hcy and reduce the level of folic acid in patients with epilepsy. Epilepsy patients taking CBZ
for a long time should be monitored for the levels of blood Hcy, folic acid, VitB12, and timely supplemented with folic
acid and B vitamins in order to prevent the occurrence of thromboembolic events.

      【Key words】 Carbamazepine; Epilepsy; Homocysteine; Folic acid; Vitamin B12
·论 著·doi:10.3969/j.issn.1003-6350.2013.01.0005