标题:早发型重度子痫前期合并低血清白蛋白患者的妊娠结局研究
作者:朱薇 1,肖美群 1,刘颖娜 2 1.暨南大学附属深圳市宝安区妇幼保健院产科,广东 深圳 518102;2.南方医科大学深圳医院妇产科,广东 深圳 518110
卷次:
2020年31卷10期
【摘要】 目的 探讨早发型重度子痫前期(sPE)合并低血清白蛋白患者的妊娠结局。方法 回顾性分析2017年10月至2019年10月在暨南大学附属深圳市宝安区妇幼保健院接受治疗的100例早发型 sPE患者的诊疗情况,根据患者入院时的血清白蛋白水平进行分组,以50例血清白蛋白为正常水平(≥30 g/L)者为观察组,50例低血清白蛋白(<30 g/L)者为对照组。两组患者均进行常规治疗,比较两组产妇的并发症发生情况以及胎儿和新生儿的状况。结果 观察组产妇的并发症总发生率为14.0%,明显低于对照组的72.0%,差异具有统计学意义(P<0.05);两组产妇的胎儿活产数比较差异无统计学意义(P>0.05);观察组产妇的胎儿生长受限率为4.0%,明显低于对照组的16.0%,新生儿窒息率为 10.0%,明显低于对照组的 26.0%,新生儿Apgar评分和出生体质量分别为(8.6±0.7)分、(1687.7±89.5) g,明显高于对照组的(7.8±0.6)分、(1423.5±60.6) g,差异均具有统计学意义(P<0.05);观察组新生儿的并发症总发生率为35.4%,明显低于对照组的70.5%,差异有统计学意义(P<0.05)。结论 早发型 sPE合并低血清白蛋白能够提高产妇的并发症发生率,增加新生儿窒息发生率、影响胎盘早剥及胎儿生长。血清白蛋白是早发型 sPE患者重要临床检测指标,一旦发现患者出现低血清白蛋白时,应警惕胎盘早剥,做好终止妊娠准备。
【关键词】 早发型重度子痫前期;低血清白蛋白;妊娠结局;并发症;母婴
【中图分类号】 R714.24+5 【文献标识码】 A 【文章编号】 1003—6350(2020)10—1269—03
Pregnancy outcome in patients with early onset severe pre-eclampsia combined with low serum albumin.
ZHUWei 1, XIAO Mei-qun 1, LIU Ying-na 2. 1. Department of Obstetrics, Shenzhen Baoan District Maternal and Child HealthCenter Affiliated to Jinan University, Shenzhen 518102, Guangdong, CHINA; 2. Department of Obstetrics and Gynecology,Shenzhen Hospital of Southern Medical University, Shenzhen 518110, Guangdong, CHINA
【Abstract】 Objective To investigate the pregnancy outcome of patients with early onset severe pre-eclampsia(sPE) combined with low serum albumin. Methods A retrospective analysis was performed on the diagnosis and treat-ment of 100 patients with early onset sPE who were treated in Bao'an District Maternal and Child Health Hospital ofShenzhen City, Jinan University from October 2017 to October 2019. According to the serum albumin level, 50 patientswith normal serum albumin level (≥30 g/L) were enrolled into the observation group, and 50 patients with low serumalbumin (< 30 g/L) were selected as the control group. Patients in both groups were treated routinely, and the inci-dence of complications and fetal and neonatal status were compared between the two groups. Results The total inci-dence of complications in the observation group was 14.0%, which was significantly lower than 72.0% in the controlgroup (P<0.05); there was no significant difference in the number of live births between the two groups of mothers (P>0.05); the fetal growth restriction rate of the mothers in the observation group was 4.0%, which was significantly low-er than 16.0% in the control group, and the neonatal asphyxia rate was 10.0% , which was significantly lower than26.0%in the control group (P<0.05); the neonatal Apgar score and newborn's body weight of the observation group were(8.6±0.7) points, (1 687.7±89.5) g, respectively, which were significantly higher than corresponding (7.8±0.6) points and(1 423.5±60.6) g of the control group (all P<0.05); the total incidence of complications in children was 35.4%, whichwas significantly lower than 70.5% in the control group (P<0.05). Conclusion Early onset sPE combined with low se-rum albumin can increase the incidence of maternal complications, increase the incidence of neonatal asphyxia, affectplacental abruption and fetal growth. Serum albumin is an important clinical detection index of early onset sPE patients.Once low serum albumin is found in patients, we should be alert to the occurrence of placental abruption and be preparedto terminate pregnancy.
【Key words】 Early onset severe preeclampsia (sPE); Low serum albumin; Pregnancy outcome; Complications;Mother and baby
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